Species: Hu
Applications: WB, Flow, IP, CyTOF-ready
Host: Goat Polyclonal
Species: Mu
Applications: WB
Host: Goat Polyclonal
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Mu
Applications: Enzyme Activity
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
KELL, also known as Kell blood group glycoprotein, is a 732 amino acid protein that is 83 kDa; expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix; links via a single disulfide bond to the XK membrane protein that carries the Kx antigen; it is a zinc endopeptidase with endothelin-3-converting enzyme activity that cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. Disease research is currently being studied with relation to KELL and tinea corporis, fetal erythroblastosis, carbuncle, erysipelas, scabies, alloimmunization, tinea, chronic granulomatous disease, tonsillitis, pneumonia, tuberculosis, protein s deficiency, acute chest syndrome, and autoimmune hemolytic anemia. This protein involvement has been observed with relation to XK, EDN1, EDN2, EDN3, and EWSR1 in proteolysis and vasoconstriction pathways.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
3792 |
| Alternate Names |
- CD238 antigen
- CD238
- EC 3.4.24.-
- ECE3
- kell blood group antigen
- kell blood group glycoprotein
- Kell blood group
- Kell blood group, metalloendopeptidase
- Kell blood group, metallo-endopeptidase
|
