JunB/AP-1 Products

Description

The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.

Bioinformatics

Entrez	16477 Mouse 24517 Rat 3726 Human
Uniprot	NP_002220 Human NP_002220.1 Human P17275 Human
Product By Gene ID	3726
Alternate Names	activator protein 1 AP-1 jun B proto-oncogene transcription factor jun-B

Research Areas for JunB/AP-1

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Phospho-Specific