Jak2 Products

Description

Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the signal transducers and activators of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, and phosphorylation at these residues is needed for Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a form of pre-B acute myeloid leukemia (4).

Bioinformatics

Entrez	16452 Mouse 24514 Rat 3717 Human
Uniprot	AAC23653 Human AAC23653. Human AF445802 Human NP_004963 Human NP_004963.1 Human O60674 Human
Product By Gene ID	3717
Alternate Names	EC 2.7.10 EC 2.7.10.2 JAK-2 Janus kinase 2Janus kinase 2 (a protein tyrosine kinase) JTK10 tyrosine-protein kinase JAK2

Research Areas for Jak2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific
Signal Transduction

Related Jak2 Blog Posts

Check out the latest blog posts on Jak2.

Using a STAT3 antibody in chromatin immunoprecipitation (ChIP) Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.

Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.

Read more Jak2 related blogs.