IL-1 RAcP/IL-1 R3 Products

Description

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).

Bioinformatics

Entrez	25466 Rat 3556 Human
Uniprot	AAH53621 Human AAH53621.1 Human AF029213 Human NM_002182 Human NM_134470 Human NP_608273.1 Human Q9NPH3 Human
Product By Gene ID	3556
Alternate Names	C3orf13IL-1RAcPIL1R3Interleukin-1 receptor 3 FLJ37788 IL-1 receptor accessory protein IL-1R3 IL-1R-3 interleukin 1 receptor accessory protein interleukin-1 receptor accessory protein beta interleukin-1 receptor accessory protein

Research Areas for IL-1 RAcP/IL-1 R3

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology