Hsp90A/B Products

Description

HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of Hsp90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90alpha exists predominantly as a homodimer while HSP90beta exists mainly as a monomer.(2) From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. (3-6) Furthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (1

Bioinformatics

Entrez	299331 Rat
Uniprot	P08238 Human
Product By Gene ID	3320
Alternate Names	FLJ31884 Heat shock 86 kDa heat shock 90kD protein 1, alpha heat shock 90kD protein 1, alpha-like 4 heat shock 90kD protein, alpha-like 4 heat shock 90kDa protein 1, alpha heat shock protein 90kDa alpha (cytosolic), class A member 1 heat shock protein HSP 90-alpha Hsp89 Hsp90 HSP90AHSP86 HSP90N HSPC1HSP 86 HSPCAHSP89A HSPCAL1 HSPCAL4 HSPN LAP2 Renal carcinoma antigen NY-REN-38