HLA DRB4 Products

Description

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Bioinformatics

Entrez	3126 Human
Uniprot	AAH05312 Human NM_021983 Human NP_068818.4 Human
Product By Gene ID	3126
Alternate Names	class II histocompatibility antigen HLA DR alpha, beta1-0307 DR12 DR-12 DR13 DR-13 DR14 DR-14 DR4 DR-4 DRB1 transplantation antigen DRB4 HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-4 beta chain HLA-DR4B human leucocyte antigen DRB4 leucocyte antigen DRB1 leukocyte antigen major histocompatibility complex, class II, DR beta 1 major histocompatibility complex, class II, DR beta 4 MHC class I antigen DRB1*12 MHC class I antigen DRB1*4 MHC class II antigen DRB1*12 MHC class II antigen DRB1*13 MHC class II antigen DRB1*14 MHC class II antigen DRB1*4 MHC class II antigen DRB4 MHC class II antigen HLA-DRB1 MHC class II antigen HLA-DR-beta MHC class II HLA-DR-beta-7 MHC class2 antigen MHC HLA DR-beta chain

Research Areas for HLA DRB4

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology