Species: Hu, Mu, Rt, Ca, Ch, Fe, Pm, Xp
Applications: WB, Simple Western, ICC/IF, IHC, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP, MA
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Dr, Po, Bv, Ch, RM
Applications: WB, ICC/IF, IHC, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, IP, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: WB, ELISA, MA, AP
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone cetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone acetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
8841 |
| Alternate Names |
- EC 3.5.1.98
- HD3RPD3-2RPD3
- histone deacetylase 3
- SMAP45
|
