HB-EGF Products

Description

HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.

Bioinformatics

Entrez	1839 Human
Uniprot	NM_001945 Human Q53H93 Human
Product By Gene ID	1839
Alternate Names	diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor) DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor) DTS DTSF heparin-binding EGF-like growth factor heparin-binding epidermal growth factor proheparin-binding EGF-like growth factor

Research Areas for HB-EGF

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Biologically Active Proteins