HARS Products

Description

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.

Bioinformatics

Entrez	15115 Mouse 3035 Human
Uniprot	AAH11807 Human NP_002100 Human NP_002100.2 Human P12081 Human
Product By Gene ID	3035
Alternate Names	cytoplasmic EC 6.1.1.21 FLJ20491 histidine-tRNA ligase histidyl-tRNA synthetase histidyl-tRNA synthetase, cytoplasmic