GM2A Products

Description

GM2A, also known as Ganglioside GM2 activator, is a 193 amino acid that is 21 kDa, with lysosome subcellular location, acts as s a lipid transfer protein that stimulates the enzymatic processing of gangliosides and T-cell activation; acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A which, together with this activator, catalyzes the degradation of the ganglioside GM2; also displays some calcium-independent phospholipase activity. Disease research on this protein has shown a relationship with tay-sachs disease, gangliosidosis, gangliosidosis gm2, sandhoff disease, neurological disorder, candidiasis, protein s deficiency, neurodegenerative disease, tay-sachs disease ab variant, spinal muscular atrophy, lysosomal storage disease, muscular atrophy, sinusitis, gastric cancer, cholesterol, and neuronitis. The GM2A protein has also shown an interaction with PLD2, GPLD1 and HEXA in the Sphingolipid metabolism, glycosphingolipid metabolism, lysosome, and phospholipid metabolism pathways.

Bioinformatics

Entrez	14667 Mouse 2760 Human 282838 Rat
Uniprot	AAH09273 Human NM_000405 Human NP_000396 Human NP_000396.2 Human P17900 Human
Product By Gene ID	2760
Alternate Names	Cerebroside sulfate activator protein ganglioside GM2 activator GM2 ganglioside activator GM2-AP SAP-3GM2 ganglioside activator protein Shingolipid activator protein 3 sphingolipid activator protein 3