Species: Hu, Pm
Applications: WB, ELISA, ICC/IF, IHC, ChIP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, ELISA, Flow, ICC/IF
Host: Goat Polyclonal
Species: Hu
Applications: WB, ICC/IF
Host: Rat Monoclonal
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
GATA1 (Globin transcription factor 1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Acquired somatic mutations in GATA1 occur in virtually all children with Down's Syndrome, congenital transient myeloproliferative syndrome (TMD) and acute megakaryocytic leukemia.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
2623 |
| Alternate Names |
- Eryf1
- ERYF1GATA-binding protein 1 (globin transcription factor 1)
- GATA binding protein 1 (globin transcription factor 1)
- GATA-1erythroid transcription factor
- GATA-binding factor 1
- GF-1
- GF1globin transcription factor 1
- NF-E1 DNA-binding protein
- NFE1erythroid transcription factor 1
- transcription factor GATA1
- XLTT
|
