GAT-1/SLC6A1 Products

Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).

Bioinformatics

Entrez	50676 Rat 6529 Human
Uniprot	NP_003033 Human P23978 Rat P30531 Human
Product By Gene ID	6529
Alternate Names	GABA Transporter 1 GABATHG GABATRGAT-1 GABT1 GAT1sodium- and chloride-dependent GABA transporter 1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Solute carrier family 6 member 1

Research Areas for GAT-1/SLC6A1

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Neuroscience