Fumarase Products

Description

Fumarase is encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Bioinformatics

Entrez	14194 Mouse 2271 Human 24368 Rat
Uniprot	AAH03108 Human NM_000143 Human NP_000134 Human NP_000134.2 Human P07954 Human
Product By Gene ID	2271
Alternate Names	EC 4.2.1.2 fumarase Fumarase fumarate hydratase fumarate hydratase, mitochondrial HLRCC LRCC MCL MCUL1

Research Areas for Fumarase

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Core ESC-Like Genes
Stem Cell Markers