FosB/G0S3 Products

Description

Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Bioinformatics

Entrez	14282 Mouse 2354 Human
Uniprot	AAH40197 Human AAH40197.1 Human NM_006732 Human NP_006723 Human P53539 Human
Product By Gene ID	2354
Alternate Names	activator protein 1 AP-1 DKFZp686C0818 FBJ murine osteosarcoma viral oncogene homolog B G0S3G0/G1 switch regulatory protein 3 GOS3 GOSB MGC42291 oncogene FOS-B protein fosB

Research Areas for FosB/G0S3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Tumor Suppressors