FLIP Products

Description

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Bioinformatics

Entrez	8837 Human
Uniprot	AAC51622 Human AAC51623 Human AAH01602 Human AAH01602.1 Human NM_003879 Human NP_001120655 Human NP_003870 Human O15519 Human
Product By Gene ID	8837
Alternate Names	CASHFADD-like antiapoptotic molecule 1 CASP8 and FADD-like apoptosis regulator CASP8AP1 Caspase homolog Caspase-eight-related protein Caspase-like apoptosis regulatory protein caspase-related inducer of apoptosis CASPER CasperFLAME1 Cellular FLICE-like inhibitory protein c-FLIPR c-FLIPS CLARPMACH-related inducer of toxicity FADD-like apoptotic molecule FLAME FLAME-1 I-FLICEMRITc-FLIPFLIPc-FLIPL Inhibitor of FLICE usurpin beta Usurpin

Research Areas for FLIP

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Signal Transduction
Tumor Suppressors

Related FLIP Blog Posts

Check out the latest blog posts on FLIP.

TRAIL-R2: The Trail Less Traveled Cells undergo apoptotic programmed cell death in response to various stimuli, and this key mechanism is necessary for cellular morphogenesis, tissue homeostasis, and host defense. Particular cytokines such as tumor necrosis factor (TNF) and the Fas li...    Read more.

Read more FLIP related blogs.