Factor XIIIa Products

Description

Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

Bioinformatics

Entrez	2162 Human 74145 Mouse
Uniprot	AAH27963 Human AAH27963.1 Human NM_000129 Human NP_000120.2 Human P00488 Human
Product By Gene ID	2162
Alternate Names	bA525O21.1 (coagulation factor XIII, A1 polypeptide) coagulation factor XIII A chain coagulation factor XIII, A1 polypeptide Coagulation factor XIIIa EC 2.3.2.13 F13Acoagulation factor XIII, A polypeptide factor XIIIa fibrin stabilizing factor, A subunit fibrinoligase FSF, A subunit Protein-glutamine gamma-glutamyltransferase A chain TGase Transglutaminase A chain transglutaminase. plasma

Research Areas for Factor XIIIa

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Apoptosis
Cancer
Cell Biology