Exosome component 6 Products

Description

The EXOSC6 gene encodes a 272 amino acid long, 28 kDA exosome complex component MTR3 protein that, even though its exact function is not known, is believed to function in the regulation of mRNA degradation. EXOSC6 requires ARE-binding proteins that recruit it to unstable mRNAs, in effect encouraging their rapid degradation. EXOSC6 has been linked to alcoholism, liver disease, hepatitis, and alcoholic hepatitis. EXOSC6 functions in ATP/ITP metabolism, deadenylation-dependent mRNA decay, destabilization of mRNA by KSRP and by BRF1, as well as regulation of mRNA stability by proteins known to bind AU-rich elements. EXOSC6 will interact with genes UPF2, SRSF3, EXOSC2, EXOSC7, and EIF3I.

Bioinformatics

Entrez	118460 Human
Uniprot	NP_478126 Human Q5RKV6 Human
Product By Gene ID	118460
Alternate Names	EAP4 exosome component 6hMtr3 hMtr3p homolog of yeast mRNA transport regulator 3 Mtr3 (mRNA transport regulator 3)-homolog MTR3mRNA transport regulator 3 homolog Mtr3p p11exosome complex exonuclease MTR3