Species: Hu, Mu
Applications: WB, ICC/IF
Host: Goat Polyclonal
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Description
The extracellular signal-regulated kinase 5 (ERK5), also known as MAPK7 or big mitogen-activated protein kinase 1 (BMK1), is a member of the MAP kinase subfamily (1). ERK5 differs considerably from other MAPKs; it contains an unusually long carboxyl-terminal tail which might contribute to the regulation of its activity and/or localization. In response to extracellular signals, ERK5 translocates to the nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors (2). ERK5 also differs from other MAPKs in possessing a potent transcriptional activation domain which mediates protein-protein interactions with the myocyte enhancer factor 2 (MEF2) transcription factors (3). ERK5 is specifically activated by MAPK kinase 5 (MAP2K5/MEK5) and plays an important role in mammary epithelial proliferation, endothelial cell survival and normal embryonic development (4-5).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
5598 |
| Alternate Names |
- Big MAP kinase 1
- BMK1 kinase
- BMK-1
- BMK1EC 2.7.11.24
- EC 2.7.11
- ERK-5
- ERK5MAPK 7
- Extracellular signal-regulated kinase 5
- extracellular-signal-regulated kinase 5
- MAP kinase 7
- mitogen-activated protein kinase 7
- PRKM7ERK4
|
![Western Blot ERK5/BMK1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/ERK5_AF2848_Western_Blot_5217.jpg)
![Immunocytochemistry ERK5/BMK1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/ERK5_AF2848_Immunocytochemistry__Immunofluorescence_19361.jpg)
