eIF3e Products

Description

Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex. There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stressresponsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.

Bioinformatics

Entrez	16341 Mouse 299872 Rat 3646 Human
Uniprot	NM_001568 Human NP_001559 Human NP_001559.1 Human P60228 Human
Product By Gene ID	3646
Alternate Names	eIF-3 p48 eIF3e eIF3-p48 EIF3S6EIF3-P48 Eukaryotic translation initiation factor 3 subunit 6 eukaryotic translation initiation factor 3 subunit E eukaryotic translation initiation factor 3, subunit 6 (48kD) eukaryotic translation initiation factor 3, subunit 6 48kDa eukaryotic translation initiation factor 3, subunit E INT6eIF3-p46 mammary tumor-associated protein INT6 murine mammary tumor integration site 6 (oncogene homolog) Viral integration site protein INT-6 homolog