EDNRB/Endothelin R Type B Products

Description

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

Bioinformatics

Entrez	13618 Mouse 1910 Human 50672 Rat
Uniprot	AAH14472 Human AAH14472.1 Human NP_000106 Human NP_001116131 Human P21451 Rat P24530 Human P48302 Mouse
Product By Gene ID	1910
Alternate Names	ABCDS endothelin B receptor Endothelin receptor non-selective type endothelin receptor type B ETB ET-B ETBR ET-BR ETRB HSCR HSCR2 WS4A

Research Areas for EDNRB/Endothelin R Type B

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuroscience
Signal Transduction