E2F-1 Products

Description

E2F1 is encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Bioinformatics

Entrez	13555 Mouse 1869 Human
Uniprot	NP_005216 Human NP_005216.1 Human Q01094 Human
Product By Gene ID	1869
Alternate Names	E2F transcription factor 1 E2F-1 PBR3 PRB-binding protein E2F-1 RBAP1 RBAP-1 RBBP3 RBBP-3 RBP3 Retinoblastoma-associated protein 1 Retinoblastoma-binding protein 3 transcription factor E2F1

Research Areas for E2F-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Phospho-Specific
Transcription Factors and Regulators