DUSP12 Products

Description

DUSP12 is encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Bioinformatics

Entrez	11266 Human
Uniprot	AAH06286.1 Human NM_007240 Human NP_009171 Human NP_009171.1 Human Q9UNI6 Human
Product By Gene ID	11266
Alternate Names	dual specificity phosphatase 12 dual specificity protein phosphatase 12 Dual specificity tyrosine phosphatase YVH1 DUSP1YVH1 protein-tyrosine phosphatase ortholog EC 3.1.3.48 serine/threonine specific protein phosphatase TDSP4 YVH1EC 3.1.3.16

Research Areas for DUSP12

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Protein Phosphatase