DPM2 Products

Description

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. (provided by RefSeq)

Bioinformatics

Entrez	8818 Human
Uniprot	NM_003863 Human NP_003854.1 Human
Product By Gene ID	8818
Alternate Names	dolichol phosphate-mannose biosynthesis regulatory protein dolichol phosphate-mannose synthase 2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit FLJ80013 MGC111193 MGC21559