DISC1 Products

Description

The Disrupted In Schizophrenia gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Bioinformatics

Entrez	244667 Mouse 27185 Human 307940 Rat
Uniprot	NM_018662 Human NP_001012975.1 Human NP_001012976 Human NP_001012977 Human NP_061132 Human NP_061132.2 Human Q810H6 Rat Q811T9 Mouse
Product By Gene ID	27185
Alternate Names	C1orf136 disrupted in schizophrenia 1 protein disrupted in schizophrenia 1 FLJ13381 FLJ21640 FLJ25311 FLJ41105 KIAA0457 SCZD9

Research Areas for DISC1

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neurodegeneration
Neuroscience

Related DISC1 Blog Posts

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Calnexin - an ER chaperone that folds the cell's glycoproteins Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...    Read more.

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