DFF45/ICAD Products

Description

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Bioinformatics

Entrez	114214 Rat 1676 Human
Uniprot	AAH07721 Human NM_004401 Human NP_004392 Human NP_004392.1 Human O00273 Human
Product By Gene ID	1676
Alternate Names	DFF1DNA fragmentation factor 45 kDa subunit DFF45DNA fragmentation factor subunit alpha DFF-45DNA fragmentation factor, 45 kD, alpha polypeptide DNA fragmentation factor, 45kDa, alpha polypeptide ICAD Inhibitor of CAD

Research Areas for DFF45/ICAD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication
Tumor Suppressors