Cytokeratin 6a Products

Description

The human type II Cytokeratin 6 (CK6; 56 kDa) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or abnormal differentiation. It has been demonstrated that CK6 isoform, CK6a, is clearly the dominant CK6 isoform in skin tissue samples and cultured epithelial cell lines and that the various isoforms are differentially regulated within and between epithelial tissue types (1). The murine genome is known to have two keratin 6 (CK6) genes, mouse CK6, CK6a and MK6b. These genes display a complex expression pattern with constitutive expression in the epithelia of oral mucosa, hair follicles, and nail beds (2). Pachyonychia congenital (PC) is characterized by hypertrophic nail dystrophy and associated ectodermal features. PC-1 subtype is associated with mutations in keratins 6a or 16, whereas PC-2 subtype is linked to mutations in keratins 6b or 17 (3).

Bioinformatics

Entrez	3853 Human
Uniprot	AAH08807.1 Human NM_005554 Human NP_005545 Human NP_005545.1 Human
Product By Gene ID	3853
Alternate Names	Allergen Hom s 5 CK6A CK-6A CK6C CK6D CK-6D cytokeratin 6A cytokeratin 6C cytokeratin 6D Cytokeratin-6A Cytokeratin-6D K6A K6C K6D keratin 6A keratin 6C keratin 6D keratin, epidermal type II, K6A keratin, type II cytoskeletal 6A Keratin-6A KRT6C KRT6D Type-II keratin Kb6

Research Areas for Cytokeratin 6a

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers
Stem Cell Markers