Cytokeratin 5 Products

Description

Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. The 58-kD keratin CK-5 is highly similar to other type II keratins and less similar to type I keratins and other intermediate filament proteins. The 58-kD keratin is regulated by retinoids in several tissues and is one of four keratins abundantly expressed in epidermal keratinocytes, where it may be important in maintaining structural integrity of the integument (1). Keratin 5 (CK-5) mRNA and protein are shown to be expressed in normal mammary epithelial cells in culture and are absent from tumor-derived cell lines. This makes CK-5 an important marker in the tumorigenic process, distinguishing normal from tumor cells, and decreased CK-5 expression correlates with tumorigenic progression (2). Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation of the flexures. Loss of function of CK-5 suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3).

Bioinformatics

Entrez	110308 Mouse 369017 Rat 3852 Human
Uniprot	AAH24292 Human AAH24292.1 Human NM_000424 Human P13647 Human
Product By Gene ID	3852
Alternate Names	58 kDa cytokeratin CK5 CK-5 Cytokeratin-5 cytokeratin-5 DDD EBS2 epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types K5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockaynetypes) keratin 5 keratin, type II cytoskeletal 5 Keratin-5 KRT5A Type-II keratin Kb5

Research Areas for Cytokeratin 5

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers

Related Cytokeratin 5 Blog Posts

Check out the latest blog posts on Cytokeratin 5.

Spheroids vs. Organoids: Which 3D Cell Culture Model is Best for You? By Jennifer Jones, M.S.Spheroids and organoids are two words that, like “butter” and “margarine”, are often referred to interchangeably but have distinct meanings. The progression and adopt...    Read more.

Read more Cytokeratin 5 related blogs.