Cortactin Products

Description

Immunocytochemistry reveals that in epithelial cells, the human cortactin protein is localized mainly in the cytoplasm and, to a very low extent, in protruding leading lamellae of the cell. However, in carcinoma cells that constitutively overexpress cortactin accumulates in the podosome-like adherens junctions associated with the cell-substratum contact sites. Overexpression and concomitant accumulation of the Cortactin protein in the cell-substratum contact sites might, therefore, contribute to the invasive potential of these tumor cells (1). In cells derived from breast carcinomas and squamous carcinomas of the head and neck, DNA amplification of a particular tyrosine kinase substrate region results in overexpression of cortactin. Overexpression is accompanied by a partial redistribution of cortactin from the cytoplasm into cell-matrix contact sites (2).

Bioinformatics

Entrez	13043 Mouse 2017 Human 60465 Rat
Uniprot	NM_005231 Human NP_005222 Human NP_005222. Human NP_005222.2 Human NP_612632 Human NP_612632.1 Human Q14247 Human Q8N707 Human
Product By Gene ID	2017
Alternate Names	1110020L01Rik Amplaxin cortactin ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 srcsubstrate) EMS1amplaxin FLJ34459 Oncogene EMS1 src substrate cortactin

Research Areas for Cortactin

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers
Phospho-Specific