CDK5 Activator 1 Products

Description

The baculoviruses are a large, diverse family of DNA viruses that have evolved a number of mechanisms to manipulate thier insect hosts. One of these is the ability to regulate apoptosis during infection by expressing proteins that can inhibit caspase activation, including the caspase inhibitor p35 and the inhibitor of apoptosis (IAP) proteins (reviewed in Clem, 2005; Clarke and Clem, 2003; and Iller, 1997). The p35 baculovirus protein strongly inhibits caspase enzymatic activity, and is the the most broadly acting caspase inhibitor protein known. p35 baculovirus forms essentially irreversible complexes with its target caspases in a process that is accompanied by the cleavage of p35, generating two fragments of approximately 10 kDa and 25 kDa. These cleavage fragments remain associated with caspases and thereby block caspase activity. The ability of p35 to inhibit caspases along with the central role of caspases in the apoptotic process enables p35 baculovirus to block apoptosis in a phylogentically broad range of cells, and in response to a wide variety of apoptotic induction signals. For example, over expression of p35 in mammalian, insect, and nematode cells results in resistance to apoptosis. IMG-5740 recognizes p35 baculovirus; p35 baculovirus migrates at ~35 kDa on SDS-PAGE.

Bioinformatics

Entrez	116671 Rat 8851 Human
Uniprot	AAH20580 Human AAH20580.1 Human NM_003885 Human Q15078 Human
Product By Gene ID	8851
Alternate Names	CDK5 activator 1 CDK5P35 CDK5R cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 regulatory subunit 1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) MGC33831 Nck5a NCK5A neuronal CDK5 activator p23 p25 p35 p35nck5a regulatory partner for CDK5 kinase tau protein kinase II 23kDa subunit TPKII regulatory subunit

Research Areas for CDK5 Activator 1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Signal Transduction