Cav1.3 Products

Description

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).; Subcellular location: Membrane; Multi-pass membrane protein.; Tissue specificity: Expressed in pancreatic islets and in brain, where it has been seen in hippocampus, basal ganglia, habenula and thalamus. No expression in skeletal muscle.

Bioinformatics

Entrez	12289 Mouse 29716 Rat 776 Human
Uniprot	Q01668 Human
Product By Gene ID	776
Alternate Names	CACN4calcium channel, neuroendocrine/brain-type, alpha 1 subunit CACNL1A2voltage-dependent L-type calcium channel subunit alpha-1D Calcium channel, L type, alpha-1 polypeptide, isoform 2 calcium channel, voltage-dependent, L type, alpha 1D subunit Cav1.3 CCHL1A2voltage-gated calcium channel alpha 1 subunit L type, alpha-1 polypeptide voltage-gated calcium channel alpha subunit Cav1.3 Voltage-gated calcium channel subunit alpha Cav1.3