Calpain 3 Products

Description

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq]

Bioinformatics

Entrez	825 Human
Uniprot	AAH03169 Human AAH03169.1 Human NP_775112 Human NP_775113 Human
Product By Gene ID	825
Alternate Names	calpain 3, (p94) Calpain L3 Calpain p94 calpain, large polypeptide L3 calpain-3 CANP 3 CANP3MGC4403 CANPL3 EC 3.4.22 EC 3.4.22.54 LGMD2 LGMD2A MGC10767 MGC11121 MGC14344 muscle-specific calcium-activated neutral protease 3 large subunit Muscle-specific calcium-activated neutral protease 3 NCL1 nCL-1large [catalytic] subunit New calpain 1