CAB39 Products

Description

Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity (1). Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms (2).

Bioinformatics

Entrez	51719 Human
Uniprot	NM_016289 Human NP_001124321 Human NP_001124322 Human NP_057373 Human NP_057373.1 Human Q9Y376 Human
Product By Gene ID	51719
Alternate Names	calcium binding protein 39 calcium-binding protein 39 FLJ22682 MO25CGI-66 Protein Mo25

Research Areas for CAB39

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Signal Transduction