beta-Synuclein Products

Description

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Bioinformatics

Entrez	104069 Mouse 113893 Rat 6620 Human
Uniprot	AAH02902 Human NM_001001502 Human NM_003085 Human NP_001001502 Human NP_001001502.1 Human NP_003076 Human Q16143 Human
Product By Gene ID	6620
Alternate Names	beta-synuclein synuclein, beta

Research Areas for beta-Synuclein

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neuroscience