ASK1 Products

Description

Apoptosis signal-regulating kinase-1 (ASK1, MEKK5, MAPKKK5) is a MAP3k type protein kinase belonging to mitogen-activated protein kinase kinase kinase (MAPKKK) family. As a regulator of JNK and p38 MAPK signaling pathways, ASK1/MEKK5 phosphorylates MMK4 to activate c-Jun N-terminal kinase (JNK) and phosphorylates MEK3 and MKK6 to activate p38. ASK1/MEKK5 is activated by oxidative stress, TNF via TRAF2, Fas via Daxx, calcium overload, and endoplasmic reticulum stress (1). ASK1/MEKK5 is inactivated by Trx, Grx, 14-3-3, and protein serine/threonine phosphatase 5 (2). While elevated level of ASK1/MEKK5 can induce apoptosis, a catalytically inactive ASK1/MEKK5 acts as an inhibitor in TNF-alpha induced apoptosis. Over-expression of ASK1/MEKK5 has also been implicated in cell differentiation, such as in keratinocyte differentiation through p38 pathway (3). ASK1/MEKK5 has been implicated as a therapeutic target for neurodegenerative disorder sand cardiac dysfunction (4).

Bioinformatics

Entrez	26408 Mouse 293015 Rat 4217 Human
Uniprot	AAH54503 Human BAA12684 Human NM_005923 Human NP_005914 Human NP_005914.1 Human Q99683 Human
Product By Gene ID	4217
Alternate Names	Apoptosis signal-regulating kinase 1 ASK-1 ASK1MEKK 5 EC 2.7.11 MAP/ERK kinase kinase 5 MAPK/ERK kinase kinase 5 MAPKKK5EC 2.7.11.25 MEK kinase 5 MEKK5apoptosis signal regulating kinase 1 mitogen-activated protein kinase kinase kinase 5

Research Areas for ASK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Protein Kinase

Related ASK1 Blog Posts

Check out the latest blog posts on ASK1.

IRE1 alpha dependent apoptotic-signaling pathway Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...    Read more.

Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis By Jamshed Arslan, Pharm. D., PhD. The most common chronic liver disorder worldwide is non-alcoholic fatty liver disease (NAFLD). This obesity-linked disorder can manifest as hepatic fat accumulation (steatosis) wit...    Read more.

Read more ASK1 related blogs.