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The mouse ADP ribosyltransferase (ART) 2.2 gene is ortholog of rat RT6, and is expressed exclusively by mature T cells. Levels of ART2.2/Art2b expression vary between inbred strains of mice and is absent in NZW mice, in which the ART2.2/Art2b gene is deleted. ART2.2/Art2b has both NAD(+) glycohydrolase and ADP ribosyltransferase activity.