NAGLU encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq]
![Enzyme Activity alpha-N-acetylglucosaminidase/NAGLU [Unconjugated]](http://images.novusbio.com/fullsize2/7096-gh_recombinant-human-naglu-protein-cf-enzyme-activity-82202312857.jpg)
![Enzyme Activity alpha-N-acetylglucosaminidase/NAGLU [Unconjugated]](http://images.novusbio.com/fullsize2/7096-gh_recombinant-human-naglu-protein-cf-enzyme-activity-822023121616.jpg)
![SDS-PAGE alpha-N-acetylglucosaminidase/NAGLU [Unconjugated]](http://images.novusbio.com/fullsize2/7096-gh_recombinant-human-naglu-protein-cf-sds-page-822023122328.jpg)