ADK Products

Description

Adenosine kinase (ATP:adenosine 5 prime phosphotransferase) is an abundant enzyme in mammalian tissues that catalyzes the transfer of the gamma phosphate from ATP to adenosine, thereby serving as a potentially important regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of ADK could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as antiinflammatory agents. The encoded protein does not present any sequence similarities to other well characterized mammalian nucleoside kinases. In contrast, 2 regions were identified with significant sequence identity to microbial ribokinase and fructokinases and a bacterial inosine/guanosine kinase. Thus, ADK is a structurally distinct mammalian nucleoside kinase that appears to be akin to sugar kinases of microbial origin.

Bioinformatics

Entrez	11534 Mouse 132 Human 25368 Rat
Uniprot	AAH03568 Human NP_001114 Human NP_006712 Human P55263 Human
Product By Gene ID	132
Alternate Names	adenosine kinase AKAdenosine 5'-phosphotransferase EC 2.7.1 EC 2.7.1.20

Research Areas for ADK

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism