Bestrophin 1 Products

Description

Bestrophin 1 (BEST1) is a member of the bestrophin family of anion channels. Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. Bestrophins are believed to function as chloride channels.

Bestrophin-1, also known as best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an inherited autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). Bestrophin 1 is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin 1's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin-1 is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.

Bestrophin antibodies are useful tools for studies involving vision and retinal disease. .

Bioinformatics

Entrez	293735 Rat 7439 Human
Uniprot	AAH41664 Human AAH41664.1 Human O76090 Human
Product By Gene ID	7439
Alternate Names	ARB Best disease BEST bestrophin 1 bestrophin-1 BMD TU15B vitelliform macular dystrophy 2 Vitelliform macular dystrophy protein 2 VMD2RP50

Research Areas for Bestrophin 1

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Sensory Systems
Vision

Related Bestrophin 1 Blog Posts

Check out the latest blog posts on Bestrophin 1.

"I can see clearly now": Targeting Bestrophin 1 to treat Bestrophinopathies Encoded by the VMD2 gene on chromosome 11q13 Bestrophin 1 is the prototypic member of the RFP family of proteins which are more commonly called "bestrophins". The protein family was originally identified in Caenorhabditis elegans based on a conserved ...    Read more.

Bestrophin 1: Implications in Progressive Vision Loss The human Bestrophin family has four members, Best1, Best2, Best3 and Best4. These transmembrane proteins can function as chloride channels, and can also regulate calcium channels (1). The Bestrophins all have a conserved domain which begins at the N-...    Read more.

Vision Infographic: Do you see how I see? Vision involves several parts of the eye processing light which send signals to the brain via the optic nerve to process information. Learn more about the vision process and related ocular proteins in the infographic below. Novus Biological...    Read more.

Read more Bestrophin 1 related blogs.