Bad Products

Description

Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.

Bioinformatics

Entrez	12015 Mouse 572 Human 64639 Rat
Uniprot	AAH01901 Human AAH01901.1 Human NM_032989 Human NP_004313 Human NP_004313.1 Human NP_031548 Mouse NP_116784 Human NP_116784 Human Q92934 Human Q92934 Human
Product By Gene ID	572
Alternate Names	BBC2 BBC6 bcl2 antagonist of cell death BCL2-antagonist of cell death protein BCL2-associated agonist of cell death Bcl-2-binding component 6 BCL2-binding component 6 BCL2-binding protein Bcl2-L-8 BCL2L8bcl2-L-8 Bcl-2-like protein 8 BCL-X/BCL-2 binding protein Bcl-XL/Bcl-2-associated death promoter

Research Areas for Bad

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
GPCR
Neuroscience
Phospho-Specific
Tumor Suppressors

Related Bad Blog Posts

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Altered expression of BCL2 in cancer Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease.  For example, too little cell death can promote cell overgrowth a...    Read more.

Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis? Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death.  Novus Biologicals offers a variet...    Read more.

AKT Antibody Assays: A Complex Area with an Easy Solution We at Novus Biologicals place a lot of emphasis on the kinase signaling pathways. Kinases, or phosphotransferase enzymes play a key role in phosphorylation signaling. Over 500 human protein kinases have so far been discovered. They play essential role...    Read more.

Cytochrome C - a mediator of apoptosis Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...    Read more.

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