ATG16L1 Products

Description

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane. There are 5 isoforms of this protein (in human), with theoretical molecular weights ranging from ~19-68 kDa.

Mutations in the ATG16L1 proitein have been associated with Crohn's disease.

Bioinformatics

Entrez	363278 Rat 55054 Human 77040 Mouse
Uniprot	A5YM60 Human NP_060444.3 Human NP_110430 Human NP_110430.5 Human Q676U5 Human Q8C0J2 Mouse
Product By Gene ID	55054
Alternate Names	APG16 autophagy 16-like (S. cerevisiae) APG16L beta APG16LFLJ10828 APG16-like 1 ATG16 autophagy related 16-like (S. cerevisiae) ATG16 autophagy related 16-like 1 (S. cerevisiae) ATG16A ATG16L autophagy-related protein 16-1 FLJ00045 FLJ10035 FLJ22677 IBD10 WD repeat domain 30 WDR30

Research Areas for ATG16L1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cell Biology
Neurodegeneration
Neuroscience
Phospho-Specific
Tumor Suppressors
Ubiquitin Proteasome Pathway

Related ATG16L1 Blog Posts

Check out the latest blog posts on ATG16L1.

Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis By Jamshed Arslan, Pharm. D., PhD. The most common chronic liver disorder worldwide is non-alcoholic fatty liver disease (NAFLD). This obesity-linked disorder can manifest as hepatic fat accumulation (steatosis) wit...    Read more.

ATG16L1 - a key player in the development of the autophagosome Like apoptosis, autophagy is a highly regulated physiologic process that involves cellular degradation and recycling of organelles and macromolecules. Autophagy is a survival mechanism induced by states of stress, starvation, and infection. A do...    Read more.

Read more ATG16L1 related blogs.