ATF4 Products

Description

ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

Bioinformatics

Entrez	11911 Mouse 468 Human 79255 Rat
Uniprot	AAH08090 Human AAH16855 Human NP_001666 Human NP_001666.2 Human P18848 Human Q06507 Mouse
Product By Gene ID	468
Alternate Names	activating transcription factor 4 (tax-responsive enhancer element B67) Activating transcription factor 4 cAMP-dependent transcription factor ATF-4 cAMP-responsive element-binding protein 2 CREB-2DNA-binding protein TAXREB67 cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-responsive element-binding protein 2 TaxREB67 TAXREB67CREB2cAMP response element-binding protein 2 Tax-responsive enhancer element-binding protein 67 TXREB

Research Areas for ATF4

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Phospho-Specific
Unfolded Protein Response

Related ATF4 Blog Posts

Check out the latest blog posts on ATF4.

The effects of ethanol consumption on glutamate production and xCT xCT is a sodium independent glutamate transporter that regulates the exchange of extracellular l-cystine and intracellular l-glutamate across the plasma membrane. This process is critical to glutathione production and protection from subsequent ox...    Read more.

CENPF Antibodies as Potential Cancer Markers Centromere protein F (CENPF), also named mitosin, is a large human protein of 3113 amino acid residues. Its expression and localization are cell cycle-dependent. The protein levels are low in G1 phase but elevated from S to early M phase. CENPF is a n...    Read more.

eIF2alpha - a regulator of global translation in response to cellular stress Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...    Read more.

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