The biological importance of protein phosphorylation is underlined by the existence of 500 or more protein kinases within the human genome. In most cases, phosphorylation of serine residues creates binding surfaces for a variety of phospho-amino acid binding proteins. Phosphorylation is a key post-translational modification necessary for normal cell signaling and is a key player in cellular function. Phosphorylated proteins mediate cell division, differentiation, signal transduction and other key cell signaling processes.
Phosphorylation of serine residues on proteins is one of the key triggers to a cascade of reactions that follow and are of great interest to several researchers. Phosphorylation of several proteins within the cells and tissues at serine residues has been detected by Immunoflorescence, Immunochemistry and by western blotting using anti-Phosphoserine antibodies in several types of cancers (1), neurological disorders (2) and in several other chronic diseases (3). Phosphorylation of pathogenic proteins is a routine phenomenon that contributes to the disease process and hyper-phosphorylation of aberrant and pathological proteins at serine residues offers a viable strategy for therapeutic interventions.
Novus Biologicals offers various phosphoserine reagents for your products research needs including:
