MMP2 antibodies have proven to be important tools for cancer research and extracellular matrix studies. Novus Biologicals offers an excellent MMP2 antibody (Catalog Number NB200-114) for Western blot, immunoprecipitation, ELISA, and immunohistochemical/immunofluorescence staining in human, mouse and rat samples. Originally developed in 2005, this MMP-2 clone (8B4) has been thoroughly characterized and cited in a growing number of published journal articles. Clone MMP2/8B4 is now considered a one of the best available commercial antibodies for MMP2 immunostaining.
MMP2 is a Matrix Metalloproteinase (MMP) family member involved in extracellular matrix degradation under both normal and diseased physiological processes. Specifically, MMP-2 initiates the degradation of collagens type IV, V, VII, and X and gelatin type I. Additionally, MMP 2 has shown involvement in angiogenesis, tumor invasion, tissue repair, remodeling of the vasculature, inflammation, and atherosclerotic plaque rupture.
MMP2 is predominantly expressed in normal skin fibroblasts, but is also detected in some tumors, such as gliomas, breast and prostate. MMP-2 gene mutations can lead to Torg-Winchester syndrome, Nodulosis-Arthropathy-Osteolysis (NAO) syndrome, and arthritis. However, abnormal expression of matrix matalloproteinases has also been linked to neoplastic traits such as loss of negative growth regulation and high invasive potential.
Novus Biologicals offers many MMP2 reagents for your research needs including:
