The transcription factor beta protein 1 (BP1) is a member of the homeobox gene family and the distal-less subfamily. Expression of BP1 is highly tissue-specific and developmentally restricted. Among different human tissues, BP1 is found to be highly expressed in placenta, kidney and at lower levels in fetal liver (1). Such restricted pattern of expression is compatible with a specific gene function in development and/or differentiation. Transient transfection studies demonstrate that BP1 protein appears to act as a repressor of the human adult beta globin gene, through two silencers upstream of the beta globin gene (2,3).
BP1 binding site sequence upstream of beta globin gene in Asian populations has been investigated for the polymorphism in the BP1 binding site upstream of beta globin gene, so as to provide the basis for exploration of relation between polymorphisms in the BP1 binding site and beta globin expression (4,5). Beta globin gene cluster polymorphisms are known to be strongly associated with severity of beta-thalassemia in the Asian populations (6). Recent studies also indicate that BP1 genes are dysregulated in various cancers and some new studies point to an important role for BP1, an isoform of DLX4 homeobox gene, in breast carcinogenesis and progression (7). Current research directed towards the elucidation of the role of BP1 in breast tumorogenesis holds a great promise in establishing BP1 as a novel target for drug therapy.
Novus Biologicals offers BP1 reagents for your research needs including:
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