VAMP-2 Antibody

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP 25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP 2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using NB300-595	Applications	Species
Usami Y, Hatano T, Imai S et al. DJ-1 associates with synaptic membranes. Neurobiol Dis. 2011-05-30 [PMID: 21645620]
Marshall C, Hitman GA, Partridge CJ et al. Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells. Mol Endocrinol. 2005-01-01 [PMID: 15471947]
Rosado JA, Redondo PC, Salido GM et al. Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca2+ entry in mouse pancreatic acinar cells. Am J Physiol Cell Physiol. 2005-01-01 [PMID: 15355848]
Windoffer R, Borchert-Stuhltrager M, Haass NK et al. Tissue expression of the vesicle protein pantophysin. Cell Tissue Res. 1999-06-01 [PMID: 10370136]

Array NB300-595

• VAMP-2 Antibodies
• VAMP-2 Lysate
• VAMP-2 Proteins