Synaptophysin Antibody

Synaptophysin is a 38 kDa synaptic vesicle associated protein. The pathology of synaptic components is investigated by measuring the expression of synaptophysin that is mainly concentrated in synaptic terminals. The expression of synaptophysin is a measure of dynamic plastic changes in nerve tissue. A decrease in synaptophysin and other synaptic vesicle associated proteins (Synaptotagmin, synaptosomal associated protein 25 kDa, SNAP-25, CLC ad GAP-43) generally means degeneration in the nerve fibers and an increased expression results in enhanced neuroplasticity and neuronal hypertrophy. In conditions involving generative changes in the nerve tissue, the expression of psynaptophysin is generally reduced, for example, in Schizophrenia an Alzhiemers disease. A decreased expression of synaptophysin in hippocampus of Schizoprenic patients has also been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 10 of 10.

Publications using NB300-653	Applications	Species
Kumar S, Orlov E, Gowda P et al. Synaptosome microRNAs regulate synapse functions in Alzheimer's disease NPJ genomic medicine 2022-08-08 [PMID: 35941185] (WB, Mouse)	WB	Mouse
Sinopoulou E, Rosenzweig ES, Conner JM et al. Rhesus macaque versus rat divergence in the corticospinal projectome Neuron 2022-07-31 [PMID: 35917818]
Kilinc M, Arora V, Creson TK et al. Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection eLife 2022-04-08 [PMID: 35394425]
Sui L, Danzl N, Campbell SR et al. Beta Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells Diabetes 2017-09-20 [PMID: 28931519] (Human)		Human
Lam CS, Tipoe GL, Wong JK et al. M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus. PLoS ONE. 2016-11-21 [PMID: 27870896] (WB, Rat)	WB	Rat
D'Cruz TS, Weibley BN, Kimball SR, Barber AJ. Post-Translational Processing of Synaptophysin in the Rat Retina Is Disrupted by Diabetes PLoS One 2012-01-01 [PMID: 22970294] (IP, Rat)	IP	Rat
Postupna N, Rose SE, Bird TD et al. Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid Beta and paired helical filament-tau accumulation in cognitively normal older adults Brain Pathol 2012-07-01 [PMID: 21999410] (Human)		Human
Dash PK, Gorantla S, Gendelman HE, et al. Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice. J Neurosci. [PMID: 21368026] (ICC/IF, Mouse)	ICC/IF	Mouse
Kilinc M, Creson TK, Rojas C et al. Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function bioRxiv 2020-01-01 (WB, Mouse)	WB	Mouse
Erener S, Ellis CE, Ramzy A Et al. Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice Cell reports. Medicine 2021-11-16 [PMID: 34841287]

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-Fr	Feline	09/15/2018	View Summary Application Immunohistochemistry-Frozen Sample Tested Retina Species Feline Lot Pld100lg
	4 reviewed by: Brittany Weibley	IP	Rat	08/16/2010	View Summary Application Immunoprecipitation Sample Tested Rat Retinal Tissue Species Rat

Array NB300-653

• Synaptophysin Antibodies
• Synaptophysin ELISA Kits
• Synaptophysin Lysate
• Synaptophysin Proteins