SOX2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SOX2 belongs to the SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX2 functions in specifying the first three lineages present at implantation and in regulating proliferation and differentiation in the developing peripheral nervous system (1-5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 17 confirmed species: Human, Mouse, Rat, Aedes albopictus (mosquito), Avian - Quail, Bovine, Callithrix jacchus (Marmoset), Canine, Chicken, Ferret, Fish, Marmoset, Primate - Rhesus macaque, Transgenic Mouse, Xenograft, Xenopus, Zebrafish.

We have publications tested in 15 applications: Binding Assay, Bioassay, ChIP, Co-Immunoprecipitation, Dot Blot, Flow Cytometry, ICC, ICC/IF, IF, IHC, IHC-Fr, IHC-P, Immunoprecipitation, RNAScope, Western Blot.

Showing Publications 1 - 10 of 353. Show All 353 Publications. Collapse Publications.

Publications using AF2018	Applications	Species
Balashova, OA;Panoutsopoulos, AA;Visina, O;Selhub, J;Knoepfler, PS;Borodinsky, LN; Noncanonical function of folate through folate receptor 1 during neural tube formation Nature communications 2024-02-22 [PMID: 38388461] (IHC, Xenopus, Human)	IHC	Xenopus, Human
Zhu, Q;Liang, P;Meng, H;Li, F;Miao, W;Chu, C;Wang, W;Li, D;Chen, C;Shi, Y;Yu, X;Ping, Y;Niu, C;Wu, HB;Zhang, A;Bian, XW;Zhou, W; Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells Nature communications 2024-01-02 [PMID: 38167292] (IHC, Xenograft, Human)	IHC	Xenograft, Human
Saegusa, C;Kakegawa, W;Miura, E;Aimi, T;Mogi, S;Harada, T;Yamashita, T;Yuzaki, M;Fujioka, M; Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice International journal of molecular sciences 2023-12-04 [PMID: 38069416] (IHC, Mouse)	IHC	Mouse
Tao, Y;Li, X;Dong, Q;Kong, L;Petersen, AJ;Yan, Y;Xu, K;Zima, S;Li, Y;Schmidt, DK;Ayala, M;Mathivanan, S;Sousa, AMM;Chang, Q;Zhang, SC; Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells Nature biotechnology 2023-11-16 [PMID: 37974010] (IHC, Flow Cytometry, Mouse)	IHC, Flow Cytometry	Mouse
Rao, SB;Brundu, F;Chen, Y;Sun, Y;Zhu, H;Shprintzen, RJ;Tomer, R;Rabadan, R;Leong, KW;Markx, S;Xu, B;Gogos, JA; Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome and schizophrenia bioRxiv : the preprint server for biology 2023-10-05 [PMID: 37873382] (Flow Cytometry, Human)	Flow Cytometry	Human
Zhang, Y;Tian, K;Wei, W;Mi, W;Lu, F;Liu, Z;Zhu, Q;Zhang, X;Geng, P;Qiu, J;Song, Y;Zha, D; Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells Neural regeneration research 2024-05-01 [PMID: 37862217] (ICC, Mouse)	ICC	Mouse
Zhu, C;Ren, X;Liu, C;Liu, Y;Wang, Y; Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice Neural regeneration research 2024-04-01 [PMID: 37843222] (IHC, Mouse)	IHC	Mouse
Su, D;Eliason, S;Sun, Z;Shao, F;Amendt, BA; Wolf-Hirschhorn Syndrome Candidate 1 (Whsc1) Methyltransferase Signals Via a Pitx2-miR-23/24 Axis to Effect Tooth Development The Journal of biological chemistry 2023-10-06 [PMID: 37806494] (IHC, Mouse)	IHC	Mouse
She, L;Li, X;Bai, M; Generation of an induced pluripotent stem cell line XJHi001-A from a fibronectin glomerulopathy patient carrying a heterozygous NM_212482.2(C.5888-1G > C) mutation in the FN1 gene Stem cell research 2023-09-11 [PMID: 37801747] (ICC, Human)	ICC	Human
Rizzoti, K;Chakravarty, P;Sheridan, D;Lovell-Badge, R; SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context Science advances 2023-10-06 [PMID: 37792947] (IHC, Mouse)	IHC	Mouse
Jeon, HM;Shin, YJ;Lee, J;Chang, N;Woo, DH;Lee, WJ;Nguyen, D;Kang, W;Cho, HJ;Yang, H;Lee, JK;Sa, JK;Lee, Y;Kim, D;Purow, BW;Yoon, Y;Nam, DH;Lee, J; The Semaphorin 3A-Neuropilin-1 Pathway Promotes Clonogenic Growth of Glioblastoma via Activation of TGF? Signaling JCI insight 2023-10-03 [PMID: 37788099] (IHC-P, Human)	IHC-P	Human
Yin, J;Seo, Y;Rhim, J;Jin, X;Kim, TH;Kim, SS;Hong, JH;Gwak, HS;Yoo, H;Park, JB;Kim, JH; Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells Cancer research 2023-09-25 [PMID: 37747775] (Western Blot, Human)	Western Blot	Human
Maura K. Schwartz, Shibi Likhite, Tatyana A. Vetter, Megan C. Baird, Vicki McGovern, Andrea Sierra Delgado et al. In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans Molecular Therapy - Methods & Clinical Development 9/14/2023 [PMID: 37746244]
Militi, S;Nibhani, R;Jalali, M;Pauklin, S; RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling Cell reports 2023-09-18 [PMID: 37725511] (ICC, Human)	ICC	Human
Jaime Imitola, Ethan W. Hollingsworth, Fumihiro Watanabe, Marta Olah, Wassim Elyaman, Sarah Starossom et al. Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation Frontiers in Cellular Neuroscience 8/16/2023 [PMID: 37663126]
Stanton, AE;Bubnys, A;Agbas, E;James, B;Park, DS;Jiang, A;Pinals, RL;Truong, N;Loon, A;Staab, C;Liu, L;Cerit, O;Wen, HL;Kellis, M;Blanchard, JW;Langer, RS;Tsai, LH; Engineered 3D Immuno-Glial-Neurovascular Human Brain Model bioRxiv : the preprint server for biology 2023-08-17 [PMID: 37645757] (IHC, Human)	IHC	Human
Francesca Ciarpella, Raluca Georgiana Zamfir, Alessandra Campanelli, Giulia Pedrotti, Marzia Di Chio, Emanuela Bottani et al. Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells STAR Protocols 9/1/2023 [PMID: 37454299]
Chen, X;Cui, QQ;Hu, XH;Ye, J;Liu, ZC;Mei, YX;Wang, F;Hu, ZL;Chen, JG; CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation Journal of neuroinflammation 2023-06-30 [PMID: 37391731] (IHC, Mouse)	IHC	Mouse
Wang, Y;Peng, J;Song, C;Yang, Y;Qin, T; Zinc finger and SCAN domain-containing 18 suppresses the proliferation, self-renewal, and drug resistance of glioblastoma cells Heliyon 2023-06-01 [PMID: 37389038] (Western Blot, Human)	Western Blot	Human
Bismark Appiah, Camila L Fullio, Chiara Ossola, Ilaria Bertani, Elena Restelli, Arquimedes Cheffer et al. DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression EMBO reports 8/3/2023 [PMID: 37382163]
Chen, Y;Gong, C;Chauhan, S;De La Cruz, ED;Datta, MS;Tomer, R; Scalable projected Light Sheet Microscopy for high-resolution imaging of large samples bioRxiv : the preprint server for biology 2023-06-05 [PMID: 37333196] (IHC, Human)	IHC	Human
Hilansi Rawat, Jessica Kornherr, Dorota Zawada, Sara Bakhshiyeva, Christian Kupatt, Karl-Ludwig Laugwitz et al. Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models Frontiers in Cell and Developmental Biology 5/15/2023 [PMID: 37261075]
Rallapalli, H;Bayin, NS;Goldman, H;Maric, D;Nieman, BJ;Koretsky, AP;Joyner, AL;Turnbull, DH; Cell Specificity of Manganese-enhanced MRI Signal in the Cerebellum NeuroImage 2023-05-26 [PMID: 37245561] (IHC, Mouse)	IHC	Mouse
Thompson, MJ;Young, CA;Munnamalai, V;Umulis, DM; Early radial positional information in the cochlea is optimized by a precise linear BMP gradient and enhanced by SOX2 Scientific reports 2023-05-26 [PMID: 37237002] (IHC, Mouse)	IHC	Mouse
Zhu, Z;Chen, X;Guo, A;Manzano, T;Walsh, PJ;Wills, KM;Halliburton, R;Radko-Juettner, S;Carter, RD;Partridge, JF;Green, DR;Zhang, J;Roberts, CWM; Mitotic bookmarking by SWI/SNF subunits Nature 2023-06-01 [PMID: 37225980] (Bioassay, Western Blot, ICC, Mouse)	Bioassay, Western Blot, ICC	Mouse
Qing Li, Chong Cui, Rongyu Liao, Xidi Yin, Daqi Wang, Yanbo Cheng et al. The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice Cellular and Molecular Life Sciences 6/1/2023 [PMID: 37178259]
J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids Elife, 2023-03-29;12(0):. 2023-03-29 [PMID: 36989136] (ICC, IHC, Human)	ICC, IHC	Human
Xiao-Yan Tang, Da Wang, Xin-Yue Zhang, Min Xu, Yan Liu Optimized protocol for analysis of neural stem proliferation in human-pluripotent-stem-cell-derived cerebral organoids STAR Protocols 6/1/2023 [PMID: 36924505]
Richard A. Guyer, Rhian Stavely, Keiramarie Robertson, Sukhada Bhave, Jessica L. Mueller, Nicole M. Picard et al. Single-cell multiome sequencing clarifies enteric glial diversity and identifies an intraganglionic population poised for neurogenesis Cell Reports 3/28/2023 [PMID: 36857184]
Qing Luo, Han-pin Pui, Jiayu Chen, Leqian Yu, Paulo R. Jannig, Yu Pei et al. Epiblast-like stem cells established by Wnt/ beta -catenin signaling manifest distinct features of formative pluripotency and germline competence Cell Reports 1/31/2023 [PMID: 36848234]
NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome International Journal of Molecular Sciences, 2023-02-09;24(4):. 2023-02-09 [PMID: 36834891] (IHC, Human)	IHC	Human
J Li, MI Godoy, AJ Zhang, G Diamante, IS Ahn, A Cebrian-Si, A Alvarez-Bu, X Yang, BG Novitch, Y Zhang Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis bioRxiv : the preprint server for biology, 2023-02-14;0(0):. 2/14/2023 [PMID: 36824905]
Wang J, Xu L, Peng D et al. IFN-?-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury Inflammation and regeneration 2/13/2023 [PMID: 36782279]
A Tafessu, R O'Hara, S Martire, AL Dube, P Saha, VU Gant, LA Banaszynsk H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells Genome Biology, 2023-02-13;24(1):25. 2023-02-13 [PMID: 36782260] (Binding Assay, Mouse)	Binding Assay	Mouse
F Zhang, K Yoon, DY Zhang, NS Kim, GL Ming, H Song Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification Cell Stem Cell, 2023-02-09;0(0):. 2023-02-09 [PMID: 36764294] (IHC, Human)	IHC	Human
J Taubenschm, M Orthofer, A Laemmerer, C Krauditsch, M Rózsová, C Studer, D Lötsch, J Gojo, L Gabler, M Dyczynski, T Efferth, A Hagelkruys, G Widhalm, A Peyrl, S Spiegl-Kre, D Hoepfner, S Bian, W Berger, JA Knoblich, U Elling, M Horn, JM Penninger A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors Embo Molecular Medicine, 2023-02-06;0(0):e16959. 2023-02-06 [PMID: 36740985] (IHC, Human)	IHC	Human
Taichi Kashiwagi, Yuuki Takazawa, Tetsushi Kagawa, Tetsuya Taga Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia Inflammation and Regeneration 2/1/2023 [PMID: 36726165]
Marco Massimo, Carlotta Barelli, Catalina Moreno, Chiara Collesi, Rebecca K Holloway, Berta Crespo et al. Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection Brain 3/1/2023 [PMID: 36642091]
Philip L. Yates, Kendra Case, Xiaohuan Sun, Kimberly Sullivan, Peter W. Baas, Liang Qiang Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War Illness Frontiers in Cellular Neuroscience 12/23/2022 [PMID: 36619675]
C Kokorudz, BN Radford, W Dean, M Hemberger Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain Cells, 2022-12-24;12(1):. 2022-12-24 [PMID: 36611870] (IHC, Mouse)	IHC	Mouse
R Yelagandul, K Stecher, M Novatchkov, L Michetti, G Michlits, J Wang, P Hofbauer, G Vainorius, C Pribitzer, L Isbel, S Mendjan, D Schübeler, U Elling, J Brennecke, O Bell ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers Nature Cell Biology, 2023-01-05;0(0):. 2023-01-05 [PMID: 36604593] (ChIP, Mouse)	ChIP	Mouse
Zachary T. Olmsted, Maria Belen Paredes-Espinosa, Janet L. Paluh Generation of human elongating multi-lineage organized cardiac gastruloids STAR Protocols 12/16/2022 [PMID: 36595961]
Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Alejandro López-Tobón, Erika Tenderini, Sara Sebastiani et al. Benchmarking brain organoid recapitulation of fetal corticogenesis Translational Psychiatry 12/20/2022 [PMID: 36539399]
Meiyan Wang, Yuanxiao Liu, Ziwei Wang, Longliang Qiao, Xiaoding Ma, Lingfeng Hu et al. An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice Advanced Science 2/1/2023 [PMID: 36507552]
K Lim, APA Donovan, W Tang, D Sun, P He, JP Pett, SA Teichmann, JC Marioni, KB Meyer, AH Brand, EL Rawlins Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease Cell Stem Cell, 2022-12-08;30(1):20-37.e9. 2022-12-08 [PMID: 36493780] (IHC, Human)	IHC	Human
G Rastoldo, I Watabe, A Lapotre, A Tonetto, A López-Juár, B Tighilet Vestibular Nuclei: A New Neural Stem Cell Niche? Cells, 2022-11-14;11(22):. 2022-11-14 [PMID: 36429025] (IHC, Rat)	IHC	Rat
EJ Kim, JY Kim, SO Kim, N Hong, SH Choi, MG Park, J Jang, SW Ham, S Seo, SY Lee, K Lee, HJ Jeong, SJ Kim, S Jeong, K Min, SC Kim, X Jin, SH Kim, SH Kim, H Kim The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2 Cell Reports, 2022-11-22;41(8):111626. 2022-11-22 [PMID: 36417870] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
S Nakanoh, J Kadiwala, L Pinte, CM Morell, AS Lenaerts, L Vallier Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells PLoS ONE, 2022-11-22;17(11):e0269122. 2022-11-22 [PMID: 36413521] (ICC, Human)	ICC	Human
Q Zhao, K Liu, L Zhang, Z Li, L Wang, J Cao, Y Xu, A Zheng, Q Chen, T Zhao BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination Cell Death & Disease, 2022-11-19;13(11):976. 2022-11-19 [PMID: 36402748] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
X Shi, Y Zhuang, Z Chen, M Xu, J Kuang, XL Sun, L Gao, X Kuang, H Zhang, W Li, SZH Wong, C Liu, L Liu, D Jiang, D Pei, Y Lin, QF Wu Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset Science Advances, 2022-11-16;8(46):eabq2987. 2022-11-16 [PMID: 36383654] (ICC, IHC, Mouse)	ICC, IHC	Mouse
Y Su, Y Zhou, ML Bennett, S Li, M Carceles-C, L Lu, S Huh, D Jimenez-Cy, BC Kennedy, SK Kessler, AN Viaene, I Helbig, X Gu, JE Kleinman, TM Hyde, DR Weinberger, DW Nauen, H Song, GL Ming A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan Cell Stem Cell, 2022-11-03;29(11):1594-1610.e8. 2022-11-03 [PMID: 36332572] (IHC, Human)	IHC	Human
M Naruse, T Saito Immediate protein expression from exogenous mRNAs in embryonic brain Scientific Reports, 2022-10-13;12(1):17145. 2022-10-13 [PMID: 36229519] (IHC, Mouse)	IHC	Mouse
Ideno H, Imaizumi K, Shimada H, Sanosaka T, Nemoto A, Kohyama J, Okano H Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScience, 2022-09-16;25(10):105140. 2022-09-16 [PMID: 36185382] (IHC, Human)	IHC	Human
Y Li, Y Li, H Liu, L Cheng, H Ma, X Xu, N Zhang Generation of a human induced pluripotent stem cell line (LZUSHi002-A) from a MADD patient with ETFDH mutation Stem Cell Research, 2022-09-14;64(0):102914. 2022-09-14 [PMID: 36162333] (IHC, Human)	IHC	Human
Z Li, JA Klein, S Rampam, R Kurzion, NB Campbell, Y Patel, TF Haydar, E Zeldich Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome Frontiers in Neuroscience, 2022-09-07;16(0):932384. 9/7/2022 [PMID: 36161168]
Yoshiki Nakashima, Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Masayuki Matsushita, Masayoshi Tsukahara et al. Induced hepatic stem cells are suitable for human hepatocyte production iScience 10/21/2022 [PMID: 36147945]
AM Drozd, L Mariani, X Guo, V Goitea, NA Menezes, E Ferretti Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation International Journal of Molecular Sciences, 2022-09-07;23(18):. 2022-09-07 [PMID: 36142249] (ICC/IF, Mouse)	ICC/IF	Mouse
Marissa A. Lithopoulos, Xavier Toussay, Shumei Zhong, Liqun Xu, Shamimunisa B. Mustafa, Julie Ouellette et al. Neonatal hyperoxia in mice triggers long-term cognitive deficits via impairments in cerebrovascular function and neurogenesis Journal of Clinical Investigation 11/15/2022 [PMID: 36136598]
Dawei Sun, Oriol Llora Batlle, Jelle van den Ameele, John C Thomas, Peng He, Kyungtae Lim et al. SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling The EMBO Journal 11/2/2022 [PMID: 36121125]
Jennifer M Lin, Tyler A Mitchell, Megan Rothstein, Alison Pehl, Ed Zandro M Taroc, Raghu R Katreddi et al. Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2 epsilon in vomeronasal sensory neurons eLife 9/16/2022 [PMID: 36111787]
Natalia López-Anguita, Seher Ipek Gassaloglu, Maximilian Stötzel, Adriano Bolondi, Deniz Conkar, Marina Typou et al. Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids Development 10/15/2022 [PMID: 36102628]
Jan Fischer, Eduardo Fernández Ortuño, Fabio Marsoner, Annasara Artioli, Jula Peters, Takashi Namba et al. Human-specific ARHGAP11B is necessary and sufficient for human-type basal progenitor levels in primate brain organoids EMBO Rep 8/24/2023 [PMID: 36098218]
J Zhang, X Lv, B Wei, X Gong, L Chen CHD4 mediates SOX2 transcription through TRPS1 in luminal breast cancer Cellular Signalling, 2022-09-06;100(0):110464. 2022-09-06 [PMID: 36075559] (Western Blot, Human)	Western Blot	Human
E Place, E Manning, DW Kim, A Kinjo, G Nakamura, K Ohyama SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis Frontiers in Neuroscience, 2022-08-11;16(0):855288. 2022-08-11 [PMID: 36033614] (ICC/IF, Chicken)	ICC/IF	Chicken
Chia-I. Ko, Jacek Biesiada, Hesbon A. Zablon, Xiang Zhang, Mario Medvedovic, Alvaro Puga The aryl hydrocarbon receptor directs the differentiation of murine progenitor blastomeres Cell Biology and Toxicology 8/1/2023 [PMID: 36029422]
S Mukherjee, DM Luedeke, L McCoy, M Iwafuchi, AM Zorn SOX transcription factors direct TCF-independent WNT/beta-catenin responsive transcription to govern cell fate in human pluripotent stem cells Cell Reports, 2022-08-23;40(8):111247. 2022-08-23 [PMID: 36001974] (IF, Human)	IF	Human
K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems Nature Protocols, 2022-08-17;0(0):. 8/17/2022 [PMID: 35978039]
W Ren, Z Ma, L Wang, X Feng, H Yu, Y Yu Lgr5+ cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages Theranostics, 2022-07-18;12(13):5631-5644. 2022-07-18 [PMID: 35966594] (IHC, Mouse)	IHC	Mouse
Marta Portela, Daniel Jimenez-Carretero, Veronica Labrador, Maria Jose Andreu, Elvira Arza, Valeria R. Caiolfa et al. Chromatin dynamics through mouse preimplantation development revealed by single molecule localisation microscopy Biology Open 8/15/2022 [PMID: 35876820]
Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu et al. A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation Biology Open 8/15/2022 [PMID: 35876795]
Haven I. Rodocker, Arman Bordbar, Molly J. E. Larson, Rebecca G. Biltz, Lynde Wangler, Paolo Fadda et al. Breaking Mental Barriers Promotes Recovery After Spinal Cord Injury Frontiers in Molecular Neuroscience 7/7/2022 [PMID: 35875670]
Hamed AA, Kunz DJ, El-Hamamy I et al. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours Nature communications 7/19/2022 [PMID: 35853870] Details: Sup. Fig 11
D Li, Q Zhang, L Li, K Chen, J Yang, D Dixit, RC Gimple, S Ci, C Lu, L Hu, J Gao, D Shan, Y Li, J Zhang, ZM Shi, D Gu, W Yuan, Q Wu, K Yang, L Zhao, Z Qiu, D Lv, W Gao, H Yang, F Lin, Q Wang, J Man, C Li, W Tao, S Agnihotri, X Qian, Y Shi, Y You, N Zhang, JN Rich, X Wang beta2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages Oncogene, 2022-09-16;0(0):. 2022-09-16 [PMID: 35841593] (ICC, Human)	ICC	Human
IB Kim, T Lee, J Lee, J Kim, S Lee, IG Koh, JH Kim, JY An, H Lee, WK Kim, YS Ju, Y Cho, SJ Yu, SA Kim, M Oh, DW Han, E Kim, JK Choi, HJ Yoo, JH Lee Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder Oncogene, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840799] (ICC, Human)	ICC	Human
S Kedia, MR Aghanoori, KML Burns, M Subha, L Williams, P Wen, D Kopp, SL Erickson, EM Harvey, X Chen, M Hua, JU Perez, F Ishraque, G Yang Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation Oncogene, 2022-07-12;40(2):111070. 2022-07-12 [PMID: 35830814] (ICC, Human)	ICC	Human
Ria Thomas, Vishal Menon, Rakesh Mani, Jan Pruszak Glycan Epitope and Integrin Expression Dynamics Characterize Neural Crest Epithelial-to-Mesenchymal Transition (EMT) in Human Pluripotent Stem Cell Differentiation Stem Cell Reviews and Reports 12/1/2022 [PMID: 35727432]
Olmsted ZT, Paluh JL. A combined human gastruloid model of cardiogenesis and neurogenesis iScience 6/17/2022 [PMID: 35721464]
Federica Francescangeli, Maria Laura De Angelis, Rachele Rossi, Giovanni Sette, Adriana Eramo, Alessandra Boe et al. CRIPTO Is a Marker of Chemotherapy-Induced Stem Cell Expansion in Non-Small Cell Lung Cancer Frontiers in Oncology 6/2/2022 [PMID: 35719935]
NJ Dar, R Na, Q Ran Functional Deficits of 5�FAD Neural Stem Cells Are Ameliorated by Glutathione Peroxidase 4 Cells, 2022-05-28;11(11):. 2022-05-28 [PMID: 35681465] (ICC, Mouse)	ICC	Mouse
Renee F.C. Hein, Joshua H. Wu, Emily M. Holloway, Tristan Frum, Ansley S. Conchola, Yu-Hwai Tsai et al. R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development Developmental Cell 7/1/2022 [PMID: 35679862]
Laarni Grace Corales, Hitoshi Inada, Kotaro Hiraoka, Shun Araki, Shinya Yamanaka, Takako Kikkawa et al. The subcommissural organ maintains features of neuroepithelial cells in the adult mouse Journal of Anatomy 9/1/2022 [PMID: 35638289]
J Schröter, H Syring, G Göhring, S Kölker, T Opladen, GF Hoffmann, S Syrbe, S Jung-Klawi Generation of an induced pluripotent stem cell line (DHMCi008-A) from an individual with TUBA1A tubulinopathy Stem Cell Research, 2022-05-24;62(0):102818. 2022-05-24 [PMID: 35636247] (ICC, Human)	ICC	Human
T Saeki, S Yoshimatsu, M Ishikawa, CC Hon, I Koya, S Shibata, M Hosoya, C Saegusa, K Ogawa, JW Shin, M Fujioka, H Okano Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish Regenerative Therapy, 2022-05-16;20(0):165-186. 2022-05-16 [PMID: 35620640] (ICC, Human)	ICC	Human
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K Sawada Neurogenesis of Subventricular Zone Progenitors in the Premature Cortex of Ferrets Facilitated by Neonatal Valproic Acid Exposure International Journal of Molecular Sciences, 2022-04-28;23(9):. 2022-04-28 [PMID: 35563273] (IHC, Ferret)	IHC	Ferret
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Y Yang, X Chen, K Tian, C Tian, L Chen, W Mi, Q Li, J Qiu, Y Lin, D Zha Heme Oxygenase-1 Protects Hair Cells From Gentamicin-Induced Death Frontiers in Cellular Neuroscience, 2022-04-13;16(0):783346. 2022-04-13 [PMID: 35496911] (IHC, Rat)	IHC	Rat
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YQ Liu, TW Ling, HY Wang, YH Yang, WJ Song, TC Wang Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation Stem Cell Research, 2022-03-28;61(0):102768. 2022-03-28 [PMID: 35421845] (ICC, Human)	ICC	Human
P Kadur Laks, V Sontake, A Tata, Y Kobayashi, L Macadlo, K Okuda, AS Conchola, S Nakano, S Gregory, LA Miller, JR Spence, JF Engelhardt, RC Boucher, JR Rock, SH Randell, PR Tata Human distal lung maps and lineage hierarchies reveal a bipotent progenitor Nature, 2022-03-30;604(7904):111-119. 2022-03-30 [PMID: 35355018] (IHC, Human)	IHC	Human
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G Rastoldo, E Marouane, N El-Mahmoud, D Péricat, I Watabe, A Lapotre, A Tonetto, A López-Juár, A El-Ahmadi, P Caron, ME Fraysse, C Chabbert, A Zwergal, B Tighilet L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects Cells, 2022-02-16;11(4):. 2022-02-16 [PMID: 35203333] (IHC, Rat)	IHC	Rat
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I Lopez-Fabu, M Garcia-Mac, C Buondelmon, O Burmistrov, N Bonora, P Alonso-Bat, B Morant-Fer, C Vicente-Gu, D Jimenez-Bl, R Quintana-C, E Fernandez, J Llop, P Ramos-Cabr, A Sharaireh, M Guevara-Fe, L Fitzpatric, CD Thompton, TR McKay, S Storch, DL Medina, SE Mole, PO Fedichev, A Almeida, JP Bolaños Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis Nature Communications, 2022-01-27;13(1):536. 2022-01-27 [PMID: 35087090] (ICC, Human)	ICC	Human
L de Wet, A Williams, M Gillard, S Kregel, S Lamperis, LC Gutgesell, JE Vellky, R Brown, K Conger, GP Paner, H Wang, EE Platz, AM De Marzo, P Mu, JL Coloff, RZ Szmulewitz, DJ Vander Gri SOX2 mediates metabolic reprogramming of prostate cancer cells Oncogene, 2022-01-24;0(0):. 2022-01-24 [PMID: 35067686] (ChIP, Human)	ChIP	Human
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Y Liu, Z Wu, J Zhou, DKA Ramadurai, KL Mortenson, E Aguilera-J, Y Yan, X Yang, AM Taylor, KE Varley, J Gertz, PS Choi, AD Cherniack, X Chen, AJ Bass, SD Bailey, X Zhang A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer Nature Communications, 2021-12-08;12(1):7139. 2021-12-08 [PMID: 34880227] (ChIP, Human)	ChIP	Human
AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (IHC, Human, Mouse)	IHC	Human, Mouse
SB Arredondo, DT Reyes, A Herrera-So, MD Mardones, NC Inestrosa, L Varela-Nal Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease Scientific Reports, 2021-11-25;11(1):22904. 2021-11-25 [PMID: 34824314] (IHC, Mouse)	IHC	Mouse
Takahiro Wakizono, Hideyuki Nakashima, Tetsuro Yasui, Teppei Noda, Kei Aoyagi, Kanako Okada et al. Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration JCI Insight 11/22/2021 [PMID: 34806649]
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W Chen, N Liu, S Shen, W Zhu, J Qiao, S Chang, J Dong, M Bai, L Ma, S Wang, W Jia, X Guo, A Li, J Xi, C Jiang, J Kang Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring Cell Reports, 2021-11-02;37(5):109912. 2021-11-02 [PMID: 34731622] (ICC, IHC, Mouse)	ICC, IHC	Mouse
Fernando A. Vicentini, Catherine M. Keenan, Laurie E. Wallace, Crystal Woods, Jean-Baptiste Cavin, Amanda R. Flockton et al. Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia Microbiome 12/1/2021 [PMID: 34702353]
SJ Sundar, S Shakya, A Barnett, LC Wallace, H Jeon, A Sloan, V Recinos, CG Hubert Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma Translational Oncology, 2021-10-23;15(1):101251. 10/23/2021 [PMID: 34700192]
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Kazuhiko Sawada, Shiori Kamiya, Ichio Aoki The Proliferation of Dentate Gyrus Progenitors in the Ferret Hippocampus by Neonatal Exposure to Valproic Acid Frontiers in Neuroscience 9/28/2021 [PMID: 34650400]
Fan Chen, Jinpeng Liu, Robert M. Flight, Kassandra J. Naughton, Alexsandr Lukyanchuk, Abigail R. Edgin et al. Cellular Origins of EGFR‐Driven Lung Cancer Cells Determine Sensitivity to Therapy Advanced Science 11/1/2021 [PMID: 34622577]
T Fan, J He, Y Wang, J Yu, W Sun Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty Stem Cell Research, 2021-09-28;56(0):102542. 2021-09-28 [PMID: 34619645] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani et al. A functional genetic toolbox for human tissue-derived organoids eLife 10/6/2021 [PMID: 34612202]
Ellen Voigt, Madeline Wallenburg, Hannah Wollenzien, Ethan Thompson, Kirtana Kumar, Joshua Feiner et al. Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine Subtype Molecular Cancer Research 12/1/2021 [PMID: 34593608]
K Gkatzis, P Panza, S Peruzzo, DY Stainier Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures Elife, 2021-09-29;10(0):. 2021-09-29 [PMID: 34586063] (IHC, Mouse)	IHC	Mouse
V Munnamalai, NH Sammudin, CA Young, A Thawani, RJ Kuhn, DM Fekete Embryonic and Neonatal Mouse Cochleae Are Susceptible to Zika Virus Infection Viruses, 2021-09-14;13(9):. 2021-09-14 [PMID: 34578404] (IHC, Mouse)	IHC	Mouse
Brianna L. Oliver, Caryl A. Young, Vidhya Munnamalai Spatial and temporal expression of PORCN is highly dynamic in the developing mouse cochlea. Gene Expression Patterns 12/1/2021 [PMID: 34547456]
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X Huang, KM Park, P Gontarz, B Zhang, J Pan, Z McKenzie, LA Fischer, C Dong, S Dietmann, X Xing, PV Shliaha, J Yang, D Li, J Ding, T Lungjangwa, M Mitalipova, SA Khan, S Imsoonthor, N Jensen, T Wang, C Kadoch, R Jaenisch, J Wang, TW Theunissen OCT4 cooperates with distinct ATP-dependent chromatin remodelers in na�ve and primed pluripotent states in human Nature Communications, 2021-08-26;12(1):5123. 2021-08-26 [PMID: 34446700] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Lindsay A Hohsfield, Allison R Najafi, Yasamine Ghorbanian, Neelakshi Soni, Joshua Crapser, Dario X Figueroa Velez et al. Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave eLife 8/23/2021 [PMID: 34423781]
Y Kang, Y Zhou, Y Li, Y Han, J Xu, W Niu, Z Li, S Liu, H Feng, W Huang, R Duan, T Xu, N Raj, F Zhang, J Dou, C Xu, H Wu, GJ Bassell, ST Warren, EG Allen, P Jin, Z Wen A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Nature Neuroscience, 2021-08-19;0(0):. 2021-08-19 [PMID: 34413513] (ICC, Human)	ICC	Human
AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (ICC, Human)	ICC	Human
Zachary T. Olmsted, Cinzia Stigliano, Annalisa Scimemi, Tatiana Wolfe, Jose Cibelli, Philip J. Horner et al. Transplantable human motor networks as a neuron-directed strategy for spinal cord injury iScience 8/20/2021 [PMID: 34381965]
M Hosoya, M Fujioka, AY Murayama, K Ogawa, H Okano, H Ozawa Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate's Cochlea Genes, 2021-07-16;12(7):. 2021-07-16 [PMID: 34356098] (IHC, Marmoset)	IHC	Marmoset
BC Liu, FY Liu, XY Gao, YL Chen, QQ Meng, YL Song, XH Li, SQ Bao Global Transcriptional Analyses of the Wnt-Induced Development of Neural Stem Cells from Human Pluripotent Stem Cells International Journal of Molecular Sciences, 2021-07-12;22(14):. 2021-07-12 [PMID: 34299091] (ICC, Human)	ICC	Human
TA Jan, Y Eltawil, AH Ling, L Chen, DC Ellwanger, S Heller, AG Cheng Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics Cell Reports, 2021-07-13;36(2):109358. 2021-07-13 [PMID: 34260939] (ICC, IHC, RNAScope, Mouse)	ICC, IHC, RNAScope	Mouse
L Wang, D Sievert, AE Clark, S Lee, H Federman, BD Gastfriend, EV Shusta, SP Palecek, AF Carlin, JG Gleeson A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology Nature Medicine, 2021-07-09;0(0):. 2021-07-09 [PMID: 34244682] (IHC, Human)	IHC	Human
B Mao, Y Wang, T Balasubram, R Urioste, T Wafa, TS Fitzgerald, SJ Haraczy, K Edwards-Ho, ZN Sayyid, D Wilder, VSSS Sajja, Y Wei, P Arun, I Gist, AG Cheng, JB Long, MW Kelley Assessment of auditory and vestibular damage in a mouse model after single and triple blast exposures Hearing research, 2021-06-07;407(0):108292. 2021-06-07 [PMID: 34214947] (IHC, Mouse)	IHC	Mouse
Rore H, Owen N, Pina-Aguilar Re Et Al. Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells Communications biology 6/28/2021 [PMID: 34183774]
MJ MacPherson, SL Erickson, D Kopp, P Wen, MR Aghanoori, S Kedia, KML Burns, A Vitobello, F Tran Mau-T, Q Thomas, NB Gold, W Brucker, L Amlie-Wolf, KW Gripp, O Bodamer, L Faivre, M Muona, L Menzies, J Baptista, K Guegan, A Male, XC Wei, G He, Q Long, AM Innes, G Yang Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates Cell Reports, 2021-06-08;35(10):109226. 2021-06-08 [PMID: 34107259] (IHC, Mouse)	IHC	Mouse
T Zhang, T Liu, N Mora, J Guegan, M Bertrand, X Contreras, AH Hansen, C Streicher, M Anderle, N Danda, L Tiberi, S Hippenmeye, BA Hassan Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum Cell Reports, 2021-06-08;35(10):109208. 2021-06-08 [PMID: 34107249] (IHC, Mouse)	IHC	Mouse
S Yoshimatsu, R Murakami, M Nakajima, T Sato, H Kawasaki, H Okano Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability Stem Cell Research, 2021-05-11;53(0):102385. 2021-05-11 [PMID: 34088013] (ICC, Human)	ICC	Human
S Yoshimatsu, E Qian, T Sato, M Yamamoto, M Ishikawa, H Okano Establishing an induced pluripotent stem cell line from neonatal common marmoset fibroblasts by an all-in-one episomal vector approach Stem Cell Research, 2021-04-30;53(0):102380. 2021-04-30 [PMID: 34088009] (ICC, Marmoset)	ICC	Marmoset
S Yoshimatsu, K Edamura, Y Yoshii, A Iguchi, H Kondo, H Shibuya, T Sato, S Shiozawa, H Okano Non-viral derivation of a transgene-free induced pluripotent stem cell line from a male beagle dog Stem Cell Research, 2021-04-29;53(0):102375. 2021-04-29 [PMID: 34088004] (ICC, Canine)	ICC	Canine
D Gerace, KR Boulanger, J Hyoje-Ryu, DA Melton Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny Stem Cell Research, 2021-04-27;53(0):102371. 2021-04-27 [PMID: 34088000] (ICC, Human)	ICC	Human
B Hourigan, SD Balay, G Yee, S Sharma, Q Tan Capicua regulates the development of adult-born neurons in the hippocampus Scientific Reports, 2021-06-03;11(1):11725. 2021-06-03 [PMID: 34083623] (IHC, Mouse)	IHC	Mouse
Alise Zagare, Matthieu Gobin, Anna S. Monzel, Jens C. Schwamborn A robust protocol for the generation of human midbrain organoids STAR Protocols 6/1/2021 [PMID: 34027482]
H Nakashima, K Tsujimura, K Irie, T Imamura, CA Trujillo, M Ishizu, M Uesaka, M Pan, H Noguchi, K Okada, K Aoyagi, T Andoh-Noda, H Okano, AR Muotri, K Nakashima MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling Cell Reports, 2021-05-18;35(7):109124. 2021-05-18 [PMID: 34010654] (ICC, Human, Mouse)	ICC	Human, Mouse
P Filppu, JT Ramanathan, KJ Granberg, E Gucciardo, H Haapasalo, K Lehti, M Nykter, V Le Joncour, P Laakkonen CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity JCI Insight, 2021-05-10;6(9):. 2021-05-10 [PMID: 33986188] (Co-Immunoprecipitation, Western Blot, Human)	Co-Immunoprecipitation, Western Blot	Human
Rebecca J. Noort, Grace A. Christopher, Jessica L. Esseltine Pannexin 1 Influences Lineage Specification of Human iPSCs Frontiers in Cell and Developmental Biology 4/16/2021 [PMID: 33937260]
J Bayerl, M Ayyash, T Shani, YS Manor, O Gafni, R Massarwa, Y Kalma, A Aguilera-C, M Zerbib, H Amir, D Sheban, S Geula, N Mor, L Weinberger, S Naveh Tass, V Krupalnik, B Oldak, N Livnat, S Tarazi, S Tawil, E Wildschutz, S Ashouokhi, L Lasman, V Rotter, S Hanna, D Ben-Yosef, N Novershter, S Viukov, JH Hanna Principles of signaling pathway modulation for enhancing human naive pluripotency induction Cell Stem Cell, 2021-04-28;0(0):. 2021-04-28 [PMID: 33915080] (ChIP, IHC, Human, Mouse)	ChIP, IHC	Human, Mouse
JN Kuehner, J Chen, EC Bruggeman, F Wang, Y Li, C Xu, ZT McEachin, Z Li, L Chen, CM Hales, Z Wen, J Yang, B Yao 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease Cell Reports, 2021-04-27;35(4):109042. 2021-04-27 [PMID: 33910000] (Dot Blot, ICC, Western Blot, Human)	Dot Blot, ICC, Western Blot	Human
Sun Z, Cheng Z, Gong N et al. Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys Aging (Albany NY) 5/15/2021 [PMID: 33909598]
Shasha Zhang, Ying Dong, Ruiying Qiang, Yuan Zhang, Xiaoli Zhang, Yin Chen et al. Characterization of Strip1 Expression in Mouse Cochlear Hair Cells Frontiers in Genetics 4/6/2021 [PMID: 33889175]
YH Zhang, M Xu, X Shi, XL Sun, W Mu, H Wu, J Wang, S Li, P Su, L Gong, M He, M Yao, QF Wu Cascade diversification directs generation of neuronal diversity in the hypothalamus Cell Stem Cell, 2021-04-21;0(0):. 2021-04-21 [PMID: 33887179] (IHC, Mouse)	IHC	Mouse
H Mou, Y Yang, MA Riehs, J Barrios, M Shivaraju, AL Haber, DT Montoro, K Gilmore, EA Haas, B Paunovic, J Rajagopal, SO Vargas, RL Haynes, A Fine, WV Cardoso, X Ai Airway basal stem cells generate distinct subpopulations of PNECs Cell Reports, 2021-04-20;35(3):109011. 2021-04-20 [PMID: 33882306] (ICC, IHC, Human)	ICC, IHC	Human
W Mu, S Li, J Xu, X Guo, H Wu, Z Chen, L Qiao, G Helfer, F Lu, C Liu, QF Wu Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice Nature Communications, 2021-04-16;12(1):2288. 2021-04-16 [PMID: 33863883] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
N Li, SM Lin, Y Li, J Sun, L Zhang, M Chen An induced pluripotent stem cell line (GZHMCi004-A) derived from a fetus with heterozygous G380R mutation in FGFR3 gene causing achondroplasia Stem Cell Research, 2021-04-05;53(0):102322. 2021-04-05 [PMID: 33848795] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
V Krenn, C Bosone, TR Burkard, J Spanier, U Kalinke, A Calistri, C Salata, R Rilo Chris, P Pestana Ga, A Mirazimi, JA Knoblich Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly Cell Stem Cell, 2021-04-09;0(0):. 2021-04-09 [PMID: 33838105] (IHC, Human)	IHC	Human
S Yoshimatsu, R Murakami, T Sato, T Saeki, M Yamamoto, E Sasaki, T Noce, H Okano Generation of a common marmoset embryonic stem cell line CMES40-OC harboring a POU5F1 (OCT4)-2A-mCerulean3 knock-in reporter allele Stem Cell Research, 2021-03-24;53(0):102308. 2021-03-24 [PMID: 33799281] (ICC, Callithrix jacchus (Marmoset))	ICC	Callithrix jacchus (Marmoset)
Annika Zink, Pawel Lisowski, Alessandro Prigione Generation of Human iPSC-derived Neural Progenitor Cells (NPCs) as Drug Discovery Model for Neurological and Mitochondrial Disorders BIO-PROTOCOL 3/5/2021 [PMID: 33796613]
J Chen, X Dong, X Cheng, Q Zhu, J Zhang, Q Li, X Huang, M Wang, L Li, W Guo, B Sun, Q Shu, W Yi, X Li Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling Cell Reports, 2021-03-30;34(13):108905. 2021-03-30 [PMID: 33789105] (ICC, IHC, Immunoprecipitation, Western Blot, Mouse)	ICC, IHC, Immunoprecipitation, Western Blot	Mouse
D Sen, Z Drobna, AJ Keung Evaluation of UBE3A antibodies in mice and human cerebral organoids Scientific Reports, 2021-03-18;11(1):6323. 2021-03-18 [PMID: 33737669] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Ugomma C. Eze, Aparna Bhaduri, Maximilian Haeussler, Tomasz J. Nowakowski, Arnold R. Kriegstein Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia Nature Neuroscience 4/1/2021 [PMID: 33723434]
Geetika Sahni, Shu‐Yung Chang, Jeremy Teo Choon Meng, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard et al. A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects Advanced Science 3/1/2021 [PMID: 33717833]
Gang Zhao, Xiaozhen Wang, Limei Qu, Zhu Zhu, Jinghui Hong, Haiqin Hou et al. The Clinical and Molecular Characteristics of Sex-Determining Region Y-Box 2 and its Prognostic Value in Breast Cancer: A Systematic Meta-Analysis Breast Care (Basel) 1/1/2021 [PMID: 33716628]
X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021-03-02;34(9):108802. 2021-03-02 [PMID: 33657377] (ICC, Human)	ICC	Human
Y Tao, SC Vermilyea, M Zammit, J Lu, M Olsen, JM Metzger, L Yao, Y Chen, S Phillips, JE Holden, V Bondarenko, WF Block, TE Barnhart, N Schultz-Da, K Brunner, H Simmons, BT Christian, ME Emborg, SC Zhang Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys Nature Medicine, 2021-03-01;0(0):. 2021-03-01 [PMID: 33649496] (ICC, IHC, Primate - Rhesus macaque)	ICC, IHC	Primate - Rhesus macaque
A Uneda, K Kurozumi, A Fujimura, K Fujii, J Ishida, Y Shimazu, Y Otani, Y Tomita, Y Hattori, Y Matsumoto, N Tsuboi, K Makino, S Hirano, A Kamiya, I Date Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration Acta neuropathologica communications, 2021-02-22;9(1):29. 2021-02-22 [PMID: 33618763] (IHC, Western Blot, Human, Mouse)	IHC, Western Blot	Human, Mouse
Kai Xu, Xue Bai, Sen Chen, Le Xie, Yue Qiu, He Li et al. CCDC154 Mutant Caused Abnormal Remodeling of the Otic Capsule and Hearing Loss in Mice Frontiers in Cell and Developmental Biology 2/4/2021 [PMID: 33614666]
X Sun, X Zhou, B Dong, C Wang, X Xiao, Y Wang Generation of a gene-corrected isogenic iPSC line (AHQUi001-A-1) from a patient with familial hypertriglyceridemia (FHTG) carrying a heterozygous p.C310R (c.928�T�>�C) mutation in LPL gene using CRISPR/Cas9 Stem Cell Research, 2021-02-11;52(0):102230. 2021-02-11 [PMID: 33592566] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
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Yoshioka N, Gros E, Li H, Kumar S, Deacon D, Maron C, Muotri A, Chi N, Fu X, Yu B, Dowdy S Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell, 2013-08-01;13(2):246-54. 2013-08-01 [PMID: 23910086] (IHC, Human)	IHC	Human
Bareiss , Petra M, Paczulla , Anna, Wang , Hui, Schairer , Rebekka, Wiehr , Stefan, Kohlhofer , Ursula, Rothfuss , Oliver C, Fischer , Anna, Perner , Sven, Staebler , Annette, Wallwiener , Diethelm, Fend , Falko, Fehm , Tanja, Pichler , Bernd, Kanz , Lothar, Quintanilla-Martinez , Leticia, Schulze-Osthoff , Klaus, Essmann , Frank, Lengerke , Claudia SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res, 2013-07-18;73(17):5544-55. 2013-07-18 [PMID: 23867475] (IHC, Human)	IHC	Human
Cristina Ordoñez, Paz Moreno-Murciano, Maria Hernandez, Carla Di Caudo, Iñaki-Carril Mundiñano, Iñaki Carril-Mundiñano et al. Sox-2 Positive Neural Progenitors in the Primate Striatum Undergo Dynamic Changes after Dopamine Denervation PLoS ONE 6/18/2013 [PMID: 23824751]
Apostolou E, Ferrari F, Walsh R, Bar-Nur O, Stadtfeld M, Cheloufi S, Stuart H, Polo J, Ohsumi T, Borowsky M, Kharchenko P, Park P, Hochedlinger K Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell, 2013-05-09;12(6):699-712. 2013-05-09 [PMID: 23665121] (ChIP, Co-Immunoprecipitation, Mouse)	ChIP, Co-Immunoprecipitation	Mouse
Yaser Atlasi, Rubina Noori, Claudia Gaspar, Patrick Franken, Andrea Sacchetti, Haleh Rafati et al. Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation PLoS Genetics 5/2/2013 [PMID: 23658527]
Dai Q, Andreu-Agullo C, Insolera R, Wong L, Shi S, Lai E BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development, 2013-05-01;140(9):1892-902. 2013-05-01 [PMID: 23571214] (IHC, Mouse)	IHC	Mouse
Schrock A, Goke F, Wagner P, Bode M, Franzen A, Braun M, Huss S, Agaimy A, Ihrler S, Menon R, Kirsten R, Kristiansen G, Bootz F, Lengerke C, Perner S Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. PLoS ONE, 2013-03-27;8(3):e59201. 2013-03-27 [PMID: 23544055] (IHC-P, Human)	IHC-P	Human
Alissa Minkovsky, Tahsin Stefan Barakat, Nadia Sellami, Mark Henry Chin, Nilhan Gunhanlar, Joost Gribnau et al. The Pluripotency Factor-Bound Intron 1 of Xist Is Dispensable for X Chromosome Inactivation and Reactivation In Vitro and In Vivo Cell Reports 3/28/2013 [PMID: 23523354]
Juuri , Emma, Jussila , Maria, Seidel , Kerstin, Holmes , Scott, Wu , Ping, Richman , Joy, Heikinheimo , Kristiin, Chuong , Cheng-Mi, Arnold , Katrin, Hochedlinger , Konrad, Klein , Ophir, Michon , Frederic, Thesleff , Irma Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development, 2013-03-05;140(7):1424-32. 2013-03-05 [PMID: 23462476] (IHC-P, Mouse)	IHC-P	Mouse
Michael A. Lodato, Christopher W. Ng, Joseph A. Wamstad, Albert W. Cheng, Kevin K. Thai, Ernest Fraenkel et al. SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State PLoS Genetics 2/21/2013 [PMID: 23437007]
Kevin A. Peterson, Yuichi Nishi, Wenxiu Ma, Anastasia Vedenko, Leila Shokri, Xiaoxiao Zhang et al. Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning Genes & Development 12/15/2012 [PMID: 23249739]
Iva Kelava, Isabel Reillo, Ayako Y. Murayama, Alex T. Kalinka, Denise Stenzel, Pavel Tomancak et al. Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix jacchus Cerebral Cortex 2/1/2012 [PMID: 22114084]
Gene Ananiev, Emily Cunningham Williams, Hongda Li, Qiang Chang Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model PLoS ONE 9/26/2011 [PMID: 21966470]
Seo E, Basu-Roy U, Zavadil J et al. Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Mol Cell Biol. 9/19/2011 [PMID: 21930787]
Huang B, Li T, Alonso-Gonzalez L et al. A virus-free poly-promoter vector induces pluripotency in quiescent bovine cells under chemically defined conditions of dual kinase inhibition. PLoS One. 1/1/2011 [PMID: 21912700] Details: IF (kLF4-transfected bovine cells): Fig 1C. Note: The specificity of the antibody was validated by IF with bovine cells transfected with full-length bovine kLF4 (Fig 1C).
Rijlaarsdam MA, van Herk HA, Gillis AJ Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours. Br. J. Cancer, 2011-08-16;105(6):854-63. 2011-08-16 [PMID: 21847120] (IHC-P, Human)	IHC-P	Human
Engelen E, Akinci U, Bryne JC Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat. Genet., 2011-05-01;43(6):607-11. 2011-05-01 [PMID: 21532573] (ChIP, ICC, Human)	ChIP, ICC	Human
Theresia Wilbertz, Patrick Wagner, Karen Petersen, Ann-Cathrin Stiedl, Veit J Scheble, Sebastian Maier et al. SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer Modern Pathology 7/1/2011 [PMID: 21460799]
Belgacem YH, Borodinsky LN Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc. Natl. Acad. Sci. U.S.A., 2011-02-28;108(11):4482-7. 2011-02-28 [PMID: 21368195] (IHC, Xenopus)	IHC	Xenopus
Tiffany A. Heanue, Vassilis Pachnis Prospective Identification and Isolation of Enteric Nervous System Progenitors Using Sox2 Stem Cells 2/1/2011 [PMID: 21280162]
Claudia Lengerke, Tanja Fehm, Ralf Kurth, Hans Neubauer, Veit Scheble, Friederike Müller et al. Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma BMC Cancer 12/1/2011 [PMID: 21276239]
Xuefeng Fang, Jae-Geun Yoon, Lisha Li, Wei Yu, Jiaofang Shao, Dasong Hua et al. The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis BMC Genomics 12/1/2011 [PMID: 21211035]
Klim JR, Li L, Wrighton PJ A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat. Methods, 2010-11-14;7(12):989-94. 2010-11-14 [PMID: 21076418] (ICC, Human)	ICC	Human
Demarque M, Spitzer NC Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron, 2010-07-29;67(2):321-34. 2010-07-29 [PMID: 20670838] (IHC-Fr, Xenopus)	IHC-Fr	Xenopus
Chng Z, Teo A, Pedersen RA, Vallier L SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell, 2010-01-08;6(1):59-70. 2010-01-08 [PMID: 20074535] (ChIP, Human)	ChIP	Human
Si B. Sonne, Rebecca M. Perrett, John E. Nielsen, Melissa A. Baxter, David M. Kristensen, Henrik Leffers et al. Analysis of SOX2 expression in developing human testis and germ cell neoplasia The International Journal of Developmental Biology 4/26/2012 [PMID: 19876845]
Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, Squire JA, Smith A, Dirks P Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell, 2009-06-05;4(6):568-80. 2009-06-05 [PMID: 19497285] (ICC, Human)	ICC	Human
Bourguignon LY, Peyrollier K, Xia W, Gilad E Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J. Biol. Chem., 2008-04-25;283(25):17635-51. 2008-04-25 [PMID: 18441325] (Western Blot, Human)	Western Blot	Human
Fong H, Hohenstein KA, Donovan PJ Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells, 2008-04-03;26(8):1931-8. 2008-04-03 [PMID: 18388306] (ICC, Human)	ICC	Human
Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell, 2008-01-01;13(1):69-80. 2008-01-01 [PMID: 18167341] (ICC, IHC, Human, Mouse)	ICC, IHC	Human, Mouse
Vue TY, Aaker J, Taniguchi A Characterization of progenitor domains in the developing mouse thalamus. J. Comp. Neurol., 2007-11-01;505(1):73-91. 2007-11-01 [PMID: 17729296] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 2007-06-27;448(7150):196-9. 2007-06-27 [PMID: 17597760] (ICC, Mouse)	ICC	Mouse
Walton NM, Sutter BM, Laywell ED, Levkoff LH, Kearns SM, Marshall GP, Scheffler B, Steindler DA Microglia instruct subventricular zone neurogenesis. Glia, 2006-12-01;54(8):815-25. 2006-12-01 [PMID: 16977605] (ICC, Mouse)	ICC	Mouse
Show All 353 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Bhavin Shah	IHC-FrFl	Mouse	04/28/2020	View Summary Application Immunohistochemistry Free-Floating Sample Tested Adult brain Species Mouse Lot VRY0516091 Comments Comments The samples were PFA fixed. Further treatment was in Methanol. Blocking and Staining was done with 10%NDS in PBST for primary (Overnight at 4 degrees) and secondary (RT-2hrs)
	4 reviewed by: Verified Customer	IHC-Fr	Feline	07/15/2019	View Summary Application Immunohistochemistry-Frozen Sample Tested Optic nerve Species Feline Lot KOY0318041
	4 reviewed by: Verified Customer	IHC-P	Human	01/06/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 22489004 Species Human
	4 reviewed by: Verified Customer	IHC-Fr	Mouse	01/06/2015	View Summary Application Immunohistochemistry-Frozen Sample Tested See PMID 23228673 Species Mouse
	4 reviewed by: Verified Customer	IF	Other	01/06/2015	View Summary Application Immunofluorescence Sample Tested See PMID19923274 Species Other
	4 reviewed by: Verified Customer	ChIP	Human	01/06/2015	View Summary Application Chromatin Immunoprecipitation Sample Tested See PMID 23159369 Species Human

Array AF2018

• SOX2 Antibodies
• SOX2 Lysate
• SOX2 Proteins