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Otx2 Antibody [Unconjugated]

Name: Otx2 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF1979
Rating: 4.5 (2 reviews)

(163 Publications)

(2 Reviews)

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Western blot shows lysates of IMR-32 human neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Otx2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1979) followed by ...read more

Otx2 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line using Goat Anti-Human Otx2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1979) at 10 µg/mL for 3 hours at room ...read more

Otx2 was detected in immersion fixed paraffin-embedded sections of mouse embryo (14 d.p.c.) using Goat Anti-Human Otx2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1979) at 1 µg/mL for 1 hour at ...read more

Simple Western lane view shows lysates of IMR‑32 human neuroblastoma cell line, loaded at 0.2 mg/mL. A specific band was detected for Otx2 at approximately 48 kDa (as indicated) using 10 µg/mL of Goat ...read more

Generation and characterization of systemic lupus erythematosus (SLE)‐specific human‐induced pluripotent stem cells (hiPSCs). (A) Dermal fibroblasts derived from patient with SLE were reprogrammed into iPSCs using ...read more

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, IHC, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

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Biotin BAF1979

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Carrier Free AF1979-SP

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Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF1979

Otx2 Antibody [Unconjugated] Summary

Immunogen	E. coli-derived recombinant human Otx2 Met1-Leu289 Accession # P32243
Specificity	Detects human Otx2 in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	OTX2
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

Immunocytochemistry 5-15 ug/mL
Immunohistochemistry 1-15 ug/mL
Simple Western 10 ug/mL
Western Blot 1 ug/mL

Reviewed Applications

Read 2 Reviews rated 4.5

using
AF1979 in the following applications:

Immunocytochemistry

Publications

Read Publications using
AF1979 in the following applications:

Bioassay
1 publication
Cell Culture
1 publication
Differentiation
2 publications
Flow Cytometry
12 publications
ICC
56 publications
IF
1 publication
IHC
29 publications
IHC-Fr
4 publications
IHC-P
2 publications
IHC/IF
1 publication
Western Blot
5 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Otx2 Antibody [Unconjugated]

homeobox protein OTX2
MCOPS5
MGC45000
orthodenticle homeobox 2
orthodenticle homolog 2 (Drosophila)
Orthodenticle homolog 2
Otx2

Background

Otx2 is a member of the bicoid subfamily of homeodomain-containing transcription factors. It may play a role in brain and sensory organ development (1). Isoform a differs from isoform b by having an eight amino acid residue insertion between P32 and A33 of Otx2b.

Nagao, T. et al. (1998) Proc. Natl. Acad. Sci. USA 95:3737.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Otx2 Antibody
[Unconjugated]

AF1979

Species: Hu

Applications: WB, Simple Western, IHC, ICC/IF

Publications for Otx2 Antibody (AF1979)(163)

We have publications tested in 10 confirmed species: Human, Mouse, Rat, Chicken, Medaka, Pan troglodytes (Chimpanzee), Porcine, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Transgenic Mouse, Zebrafish.

We have publications tested in 11 applications: Bioassay, Cell Culture, Differentiation, Flow Cytometry, ICC, IF, IHC, IHC-Fr, IHC-P, IHC/IF, Western Blot.

Showing Publications 1 - 10 of 163. Show All 163 Publications.

Publications using AF1979	Applications	Species
Daya, NM;Döring, K;Zhuge, H;Volke, L;Stab, V;Dietz, J;Athamneh, M;Roos, A;Zaehres, H;Güttsches, AK;Mavrommatis, L;Vorgerd, M; Generation of two hiPSCs lines of two patients carrying truncating mutations in the dimerization domain of filamin C Stem cell research 2024-01-27 [PMID: 38309149] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Tripathi, D;Manhas, A;Noishiki, C;Wu, D;Adkar, S;Sallam, K;Fukaya, E;Leeper, NJ;Sayed, N; Generation of induced pluripotent stem cell line from a patient suffering from arterial calcification due to deficiency of CD73 (ACDC) Stem cell research 2023-12-19 [PMID: 38199067] (IHC, Human)	IHC	Human
Maimaitili, M;Chen, M;Febbraro, F;Ucuncu, E;Kelly, R;Niclis, JC;Christiansen, JR;Mermet-Joret, N;Niculescu, D;Lauritsen, J;Iannielli, A;Klæstrup, IH;Jensen, UB;Qvist, P;Nabavi, S;Broccoli, V;Nykjær, A;Romero-Ramos, M;Denham, M; Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells Nature communications 2023-12-05 [PMID: 38052784] (IHC, ICC, Human, Rat)	IHC, ICC	Human, Rat
Driver, K;Vo, C;Scriba, CK;Saker, S;Larmonier, T;Malfatti, E;Romero, NB;Ravenscroft, G;Laing, NG;Taylor, RL;Clayton, JS; Generation of two induced pluripotent stem cell lines from a 33-year-old central core disease patient with a heterozygous dominant c.14145_14156delCTACTGGGACA (p.Asn4715_Asp4718del) deletion in the RYR1 gene Stem cell research 2023-11-22 [PMID: 38029555] (ICC, Human)	ICC	Human
Tao, Y;Li, X;Dong, Q;Kong, L;Petersen, AJ;Yan, Y;Xu, K;Zima, S;Li, Y;Schmidt, DK;Ayala, M;Mathivanan, S;Sousa, AMM;Chang, Q;Zhang, SC; Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells Nature biotechnology 2023-11-16 [PMID: 37974010] (IHC, Flow Cytometry, Mouse)	IHC, Flow Cytometry	Mouse
Meyer, K;Lammers, NC;Bugaj, LJ;Garcia, HG;Weiner, OD; Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation Nature communications 2023-10-30 [PMID: 37903793] (ICC, Mouse)	ICC	Mouse
Balducci, V;Scardigli, F;Harakalova, M;Peter van Tintelen, J;Doevendans, PA;Costa, KD;Turnbull, IC;P G Sluijter, J;Stillitano, F; Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative Stem cell research 2023-09-21 [PMID: 37748331] (ICC, Human)	ICC	Human
Maura K. Schwartz, Shibi Likhite, Tatyana A. Vetter, Megan C. Baird, Vicki McGovern, Andrea Sierra Delgado et al. In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans Molecular Therapy - Methods & Clinical Development 2023-09-14 [PMID: 37746244]
Liu, W;Zeng, W;Kong, X;Htet, M;Yu, R;Wheeler, M;Day, JW;Wu, JC; Generation of two induced pluripotent stem cell lines from Duchenne muscular dystrophy patients Stem cell research 2023-09-18 [PMID: 37740996] (ICC, Flow Cytometry, Human)	ICC, Flow Cytometry	Human
Kenyu Iwatsuki, Mami Oikawa, Hisato Kobayashi, Christopher A. Penfold, Makoto Sanbo, Takuya Yamamoto et al. Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells Cell Reports Methods 2023-08-28 [PMID: 37671016]
Jourdon, A;Wu, F;Mariani, J;Capauto, D;Norton, S;Tomasini, L;Amiri, A;Suvakov, M;Schreiner, JD;Jang, Y;Panda, A;Nguyen, CK;Cummings, EM;Han, G;Powell, K;Szekely, A;McPartland, JC;Pelphrey, K;Chawarska, K;Ventola, P;Abyzov, A;Vaccarino, FM; Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis Nature neuroscience 2023-08-10 [PMID: 37563294] (IHC, Human)	IHC	Human
Cunningham, D;Stanberry, I;Ye, S;Alonzo, M;Zhao, MT;Garg, V;Lilly, B; Generation of iPSC line NCHi012-A from a patient with Alagille syndrome and heterozygous pathogenic variant in the JAG1 gene Stem cell research 2023-08-01 [PMID: 37549562] (ICC, Human)	ICC	Human
Mehmet Girgin, Nicolas Broguiere, Lorenzo Mattolini, Matthias Lutolf A New Approach to Generate Gastruloids to Develop Anterior Neural Tissues BIO-PROTOCOL 2023-07-20 [PMID: 37497450]
Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou et al. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo Neural Regeneration Research 2024-02-01 [PMID: 37488911]
Muwan Chen, Jonathan Christos Niclis, Mark Denham Protocol for generating reproducible miniaturized controlled midbrain organoids STAR Protocols 2023-09-01 [PMID: 37481727]
Yu Y, Alonzo M, Ye S et al. Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease Stem Cell Research 2023-09-01 [PMID: 37392705]
Kaneyasu Nishimura, Emilía Sif Ásgrímsdóttir, Shanzheng Yang, Ernest Arenas A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons STAR Protocols 2023-09-01 [PMID: 37310863]
Zeng B, Liu Z, Lu Y et al. The single-cell and spatial transcriptional landscape of human gastrulation and early brain development Cell stem cell 2023-05-12 [PMID: 37192616]
W Zeng, X Kong, C Alamana, Y Liu, J Guzman, PD Pang, JW Day, JC Wu Generation of two induced pluripotent stem cell lines from spinal muscular atrophy type 1 patients carrying no functional copies of SMN1 gene Stem Cell Research, 2023-04-17;69(0):103095. 2023-04-17 [PMID: 37087898] (ICC, Human)	ICC	Human
J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang, S Shang, X Bian, C Li, L Zhang, Y Wang, Y Nie, J Fu, W Li, MA Mazid, Y Jiang, W Jia, X Wang, Y Sun, MA Esteban, Q Sun, F Zhou, Z Liu Cynomolgus monkey embryo model captures gastrulation and early pregnancy Cell Stem Cell, 2023-04-06;30(4):362-377.e7. 2023-04-06 [PMID: 37028403] (IHC, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	IHC	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G>A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
M Shigyo, Y Kobayashi, O Platoshyn, S Marsala, T Kato, N Takamura, K Yoshida, A Kishino, M Bravo-Hern, S Juhas, J Juhasova, H Studenovsk, V Proks, JD Ciacci, M Marsala Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization Cell Transplantation, 2023-01-01;32(0):9636897231163. 1/1/2023 [PMID: 36959733]
AH Kim, HM Lee, HS Kim, J Jung, H Seol, E Choi, S Lee, Y Min Choi, JK Jun, HS Kim, J Jang Establishment of TUBB3-mCherry knock-in human pluripotent stem cell line using CRISPR/Cas9 (SNUe003-A-4) Stem Cell Research, 2023-03-08;69(0):103064. 2023-03-08 [PMID: 36913849] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Elena V. Grigor’eva, Alena E. Kopytova, Elena S. Yarkova, Sophia V. Pavlova, Diana A. Sorogina, Anastasia A. Malakhova et al. Biochemical Characteristics of iPSC-Derived Dopaminergic Neurons from N370S GBA Variant Carriers with and without Parkinson’s Disease International Journal of Molecular Sciences 2023-02-23 [PMID: 36901867]
OJ Mainwaring, H Weishaupt, M Zhao, G Rosén, A Borgenvik, L Breinschmi, AD Verbaan, S Richardson, D Thompson, SC Clifford, RM Hill, K Annusver, A Sundström, KO Holmberg, M Kasper, S Hutter, FJ Swartling ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors Nature Communications, 2023-03-03;14(1):1221. 2023-03-03 [PMID: 36869047] (ICC, Western Blot, Human)	ICC, Western Blot	Human
LR Bohrer, NE Stone, NK Mullin, AP Voigt, KR Anfinson, JL Fick, V Luangphakd, B Hittle, K Powell, GF Muschler, RF Mullins, EM Stone, BA Tucker Automating iPSC generation to enable autologous photoreceptor cell replacement therapy Journal of Translational Medicine, 2023-02-28;21(1):161. 2023-02-28 [PMID: 36855199] (IHC, Human)	IHC	Human
X Ma, S Han, Y Liu, Y Chen, P Li, X Liu, L Chang, YA Chen, F Chen, Q Hou, L Hou DAPL1 prevents epithelial-mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy Cell Death & Disease, 2023-02-25;14(2):158. 2023-02-25 [PMID: 36841807] (IHC, Mouse)	IHC	Mouse
Marion Déjosez, Arturo Marin, Graham M. Hughes, Ariadna E. Morales, Carlos Godoy-Parejo, Jonathan L. Gray et al. Bat pluripotent stem cells reveal unusual entanglement between host and viruses Cell 2023-03-02 [PMID: 36812912]
C Dupont, OJM Schäffers, BF Tan, S Merzouk, EM Bindels, A Zwijsen, D Huylebroec, J Gribnau Efficient generation of ETX embryoids that recapitulate the entire window of murine egg cylinder development Science Advances, 2023-01-18;9(3):eadd2913. 2023-01-18 [PMID: 36652512] (IHC, Mouse)	IHC	Mouse
PH Zushin, Y Zhou, A Li, EA Ashley, MT Wheeler, JC Wu Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients Stem Cell Research, 2023-01-05;67(0):103019. 1/5/2023 [PMID: 36642055]
S Adhicary, S Ye, H Lin, K Texter, V Garg, MT Zhao Establishment of NCHi009-A, an iPSC line from a patient with hypoplastic left heart syndrome (HLHS) carrying a heterozygous NOTCH1 mutation Stem Cell Research, 2022-12-31;66(0):103013. 12/31/2022 [PMID: 36599283]
Ian Y. Chen, Joseph Olshausen, Dilip Thomas, Celine Lai, Tracey L. McLaughlin, Joseph C. Wu Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics Stem Cell Research 2022-12-01 [PMID: 36427473]
H Lin, SQ Ye, ZH Xu, JS Penaloza, M Aljuhani, T Vetter, MT Zhao, KL McBride Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with congenital heart disease (CHD) Stem Cell Research, 2022-10-31;65(0):102958. 10/31/2022 [PMID: 36343514]
E Boobalan, AH Thompson, RP Alur, DM McGaughey, L Dong, G Shih, ER Vieta-Ferr, IF Onojafe, VK Kalaskar, G Arno, AJ Lotery, B Guan, C Bender, O Memon, L Brinster, C Soleilhavo, L Panman, TC Badea, A Minella, AJ Lopez, SM Thomasy, A Moshiri, D Blain, RB Hufnagel, T Cogliati, K Bharti, BP Brooks Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure Investigative Ophthalmology & Visual Science, 2022-11-01;63(12):5. 2022-11-01 [PMID: 36326727] (IHC/IF, Mouse)	IHC/IF	Mouse
Aishwarya Balasankar, Shu-Yi Claire Chan, Venkata Pakala Sudheer Babu, Gary Yam, Goh Bee Tin, Shweta Singhal Dental pulp stem cells retain mesenchymal phenotype despite differentiation toward retinal neuronal fate in vitro Frontiers in Medicine 2022-10-12 [PMID: 36314029]
Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi et al. Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain Development 2022-12-01 [PMID: 36305490]
Athina Samara, Mari Spildrejorde, Ankush Sharma, Martin Falck, Magnus Leithaug, Stefania Modafferi et al. A multi-omics approach to visualize early neuronal differentiation from hESCs in 4D iScience 2022-11-18 [PMID: 36304110]
Yoshiki Nakashima, Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Masayuki Matsushita, Masayoshi Tsukahara et al. Induced hepatic stem cells are suitable for human hepatocyte production iScience 10/21/2022 [PMID: 36147945]
M Langouët, C Jolicoeur, A Javed, P Mattar, MD Gearhart, SP Daiger, M Bertelsen, L Tranebjærg, ND Rendtorff, K Grønskov, C Jespersgaa, R Chen, Z Sun, H Li, N Alirezaie, J Majewski, VJ Bardwell, R Sui, RK Koenekoop, M Cayouette Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration Science Advances, 2022-09-07;8(36):eabh2868. 2022-09-07 [PMID: 36070393] (IHC, Mouse)	IHC	Mouse
Lili Lian, Yifan Zhai, Xuejiao Wan, Linxin Chen, Zuimeng Liu, Ruona Liu et al. Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice Investigative Opthalmology & Visual Science 2022-08-26 [PMID: 36018572]
Xuan Liang, Antonia Weberling, Chun Yuan Hii, Magdalena Zernicka‐Goetz, Clare E Buckley E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities The EMBO Journal 2022-12-15 [PMID: 35993232]
M Alonzo, J Contreras, S Ye, H Lin, L Hernandez-, KL McBride, K Texter, V Garg, MT Zhao Characterization of an iPSC line NCHi006-A from a patient with hypoplastic left heart syndrome (HLHS) Stem Cell Research, 2022-08-09;64(0):102892. 2022-08-09 [PMID: 35987121] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
J Contreras, M Alonzo, S Ye, H Lin, L Hernandez-, KL McBride, K Texter, V Garg, MT Zhao Generation of an induced pluripotent stem cell line NCHi003-A from a 11-year-old male with pulmonary atresia with intact ventricular septum (PA-IVS) Stem Cell Research, 2022-08-10;64(0):102893. 2022-08-10 [PMID: 35987120] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
J Liu, GC Black, SJ Kimber, PI Sergouniot Generation of a human induced pluripotent stem cell line carrying the TYR c.575C>A (p.Ser192Tyr) and c.1205G>A (p.Arg402Gln) variants in homozygous state using CRISPR-Cas9 genome editing Stem Cell Research, 2022-07-30;64(0):102880. 2022-07-30 [PMID: 35933957] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Merrit Romeike, Stephanie Spach, Marie Huber, Songjie Feng, Gintautas Vainorius, Ulrich Elling et al. Transient upregulation of IRF1 during exit from naive pluripotency confers viral protection EMBO reports 2022-09-05 [PMID: 35852463]
J Lotila, T Hyvärinen, H Skottman, L Airas, S Narkilahti, S Hagman Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient Oncogene, 2022-07-11;63(0):102865. 2022-07-11 [PMID: 35843021] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Jonathan Eintracht, Philippa Harding, Dulce Lima Cunha, Mariya Moosajee Efficient embryoid-based method to improve generation of optic vesicles from human induced pluripotent stem cells F1000Research 2022-03-17 [PMID: 35811797]
RR Khadim, RK Vadivelu, T Utami, FG Torizal, M Nishikawa, Y Sakai Integrating Oxygen and 3D Cell Culture System: A Simple Tool to Elucidate the Cell Fate Decision of hiPSCs International Journal of Molecular Sciences, 2022-06-30;23(13):. 2022-06-30 [PMID: 35806277] (ICC, Human)	ICC	Human
IC Han, LR Bohrer, KN Gibson-Cor, LA Wiley, A Shrestha, BE Harman, C Jiao, EH Sohn, R Wendland, BN Allen, KS Worthingto, RF Mullins, EM Stone, BA Tucker Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats Cell Transplantation, 2022-01-01;31(0):9636897221104. 2022-01-01 [PMID: 35758274] (ICC, Human)	ICC	Human
Sophie Bergmann, Christopher A. Penfold, Erin Slatery, Dylan Siriwardena, Charis Drummer, Stephen Clark et al. Spatial profiling of early primate gastrulation in utero Nature 2022-09-01 [PMID: 35709828]
HM Lee, AH Kim, S Hwang, J Jung, H Seol, JJ Sung, SM Jeong, YM Choi, JK Jun, HS Kim, J Jang Generation of alphaMHC-EGFP knock-in in human pluripotent stem cell line, SNUe003-A-3 using CRISPR/Cas9-based gene targeting Stem Cell Research, 2022-04-04;61(0):102779. 2022-04-04 [PMID: 35427904] (ICC, Human)	ICC	Human
A Manhas, JWS Jahng, CD Vera, SP Shenoy, JW Knowles, JC Wu Generation of two iPSC lines from hypertrophic cardiomyopathy patients carrying MYBPC3 and PRKAG2 variants Stem Cell Research, 2022-03-31;61(0):102774. 2022-03-31 [PMID: 35413566] (ICC, Human)	ICC	Human
Walfred W. C. Tang, Aracely Castillo-Venzor, Wolfram H. Gruhn, Toshihiro Kobayashi, Christopher A. Penfold, Michael D. Morgan et al. Sequential enhancer state remodelling defines human germline competence and specification Nature Cell Biology 2022-04-01 [PMID: 35411086]
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X Tang, L Jiao, M Zheng, Y Yan, Q Nie, T Wu, X Wan, G Zhang, Y Li, S Wu, B Jiang, H Cai, P Xu, J Duan, X Lin Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice Neuroscience, 2018-01-11;0(0):. 2018-01-11 [PMID: 29337233] (IHC, Mouse)	IHC	Mouse
Noah B. Goodson, Jhenya Nahreini, Grace Randazzo, Ana Uruena, Jane E. Johnson, Joseph A. Brzezinski Prdm13 is required for Ebf3+ amacrine cell formation in the retina Developmental Biology 2018-02-01 [PMID: 29258872]
L Todd, L Suarez, C Quinn, AJ Fischer Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Mï¿½ller Glia-Derived Progenitor Cells in the Avian Retina Stem Cells, 2017-11-27;0(0):. 2017-11-27 [PMID: 29193451] (IHC, Chicken)	IHC	Chicken
Xin Huang, Sophie Balmer, Fan Yang, Miguel Fidalgo, Dan Li, Diana Guallar et al. Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling eLife 2017-11-23 [PMID: 29168693]
PA Nakamura, AA Shimchuk, S Tang, Z Wang, K DeGolier, S Ding, TA Reh Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa Elife, 2017-11-17;6(0):. 2017-11-17 [PMID: 29148976] (IHC-Fr, Mouse)	IHC-Fr	Mouse
A Chabrat, G Brisson, H Doucet-Bea, C Salesse, M Schaan Pro, A Dovonou, C Akitegetse, J Charest, S Lemstra, D Côté, RJ Pasterkamp, MI Abrudan, E Metzakopia, SL Ang, M Lévesque Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation Nat Commun, 2017-10-16;8(1):933. 10/16/2017 [PMID: 29038581]
Christo Kole, Laurence Klipfel, Ying Yang, Vanessa Ferracane, Frederic Blond, Sacha Reichman et al. Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation Molecular Therapy 2018-01-01 [PMID: 28988713]
Akiko Sakai, Ryuichiro Nakato, Yiwei Ling, Xubin Hou, Norikazu Hara, Tomoya Iijima et al. Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex Frontiers in Neuroscience 2017-05-31 [PMID: 28620275]
Young Cha, Min-Joon Han, Hyuk-Jin Cha, Janet Zoldan, Alison Burkart, Jin Hyuk Jung et al. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis Nature Cell Biology 2017-05-01 [PMID: 28436968]
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-? Aging Cell, 2016-09-22;0(0):. 2016-09-22 [PMID: 27660103] (IHC-Fr, Western Blot, Human, Porcine)	IHC-Fr, Western Blot	Human, Porcine
Lena Iwai-Takekoshi, Anna Ramos, Ari Schaler, Samuel Weinreb, Richard Blazeski, Carol Mason Retinal pigment epithelial integrity is compromised in the developing albino mouse retina Journal of Comparative Neurology 2016-12-15 [PMID: 27097562]
Renée V. Hoch, Susan Lindtner, James D. Price, John L.R. Rubenstein OTX2 Transcription Factor Controls Regional Patterning Within The Medial Ganglionic Eminence (MGE) And Regional Identity Of The Septum Cell Reports 2015-07-21 [PMID: 26166575]
Edri , Reuven, Yaffe , Yakey, Ziller , Michael, Mutukula , Naresh, Volkman , Rotem, David , Eyal, Jacob-Hirsch , Jasmine, Malcov , Hagar, Levy , Carmit, Rechavi , Gideon, Gat-Viks , Irit, Meissner , Alexande, Elkabetz , Yechiel Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun, 2015-03-23;6(0):6500. 2015-03-23 [PMID: 25799239] (ICC, Human)	ICC	Human
Ohlemacher SK, Iglesias CL, Sridhar A et al. Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells. Curr Protoc Stem Cell Biol 2/2/2015 [PMID: 25640818]
Wu Q, Fukuda K, Weinstein M, Graff J, Saga Y SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. Development, 2015-02-01;142(3):575-86. 2015-02-01 [PMID: 25605784] (IHC, Mouse)	IHC	Mouse
Wilson Patricia G, Payne Tiffany. Genetic reprogramming of human amniotic cells with episomal vectors: neural rosettes as sentinels in candidate selection for validation assays. PeerJ. 11/18/2014 [PMID: 25426336]
Zou M, Luo H, Xiang M Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn, 2014-09-16;244(1):86-97. 2014-09-16 [PMID: 25179941] (IHC, Mouse)	IHC	Mouse
Di Giovannantonio , Luca G, Di Salvio , Michela, Omodei , Daniela, Prakash , Nilima, Wurst , Wolfgang, Pierani , Alessand, Acampora , Dario, Simeone , Antonio Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development, 2013-12-11;141(2):377-88. 2013-12-11 [PMID: 24335253] (IHC, Mouse)	IHC	Mouse
Stott , Simon R, Metzakopian , Emmanoui, Lin , Wei, Kaestner , Klaus H, Hen , Rene, Ang , Siew-Lan Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. J Neurosci, 2013-05-01;33(18):8022-34. 2013-05-01 [PMID: 23637192] (IHC, Mouse)	IHC	Mouse
Stefanie Reyes, Yuhong Fu, Kay L. Double, Veronica Cottam, Lachlan H. Thompson, Deniz Kirik et al. Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease Neurobiology of Aging 2013-03-01 [PMID: 22926168]
Yuki Muranishi, Koji Terada, Tatsuya Inoue, Kimiko Katoh, Toshinori Tsujii, Rikako Sanuki et al. An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination The Journal of Neuroscience 2011-11-16 [PMID: 22090505]
Rijlaarsdam MA, van Herk HA, Gillis AJ Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours. Br. J. Cancer, 2011-08-16;105(6):854-63. 2011-08-16 [PMID: 21847120] (IHC-P, Human)	IHC-P	Human
Lindsay Hayes, Zhiwei Zhang, Paul Albert, Mark Zervas, Sohyun Ahn The Timing of Sonic Hedgehog and Gli1 Expression Segregates Midbrain Dopamine Neurons The Journal of Comparative Neurology 2011-10-15 [PMID: 21713771]
Di Salvio M, Di Giovannantonio LG, Acampora D Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat. Neurosci., 2010-11-07;13(12):1481-8. 2010-11-07 [PMID: 21057506] (IHC-P, Mouse)	IHC-P	Mouse
Zeng H, Guo M, Martins-Taylor K Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS ONE, 2010-07-29;5(7):e11853. 2010-07-29 [PMID: 20686615] (ICC, Human)	ICC	Human
Bao-Yang Hu, Su-Chun Zhang Directed Differentiation of Neural-stem cells and Subtype-Specific Neurons from hESCs Cellular Programming and Reprogramming 2010-09-21 [PMID: 20336520]
Gil JE, Woo DH, Shim JH, Kim SE, You HJ, Park SH, Paek SH, Kim SK, Kim JH Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. FEBS Lett., 2009-01-20;583(3):561-7. 2009-01-20 [PMID: 19162023] (ICC, Human)	ICC	Human
Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells, 2007-03-01;25(6):1511-20. 2007-03-01 [PMID: 17332508] (ICC, Human)	ICC	Human
Show All 163 Publications. Collapse Publications.

Reviews for Otx2 Antibody (AF1979) (2) 4.52

Average Rating: 4.5

(Based on 2 reviews)

We have 2 reviews tested in 2 species: Mouse, pleurodeles waltl.

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reviewed by:
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ICC

pleurodeles waltl

03/30/2020

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Application	Immunocytochemistry
Sample Tested	brain
Species	pleurodeles waltl
Lot	KNO0919021

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reviewed by:
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ICC

Mouse

08/04/2016

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Application	Immunocytochemistry
Sample Tested	R1 wild type Mouse embryonic Stem Cells
Species	Mouse
Lot	KNO0615111

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SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107).

Goat IgG Isotype Control [Unconjugated]
AB-108-C

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	Verified Customer 03/30/2020
Application:	ICC
Species:	pleurodeles waltl

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	Verified Customer 08/04/2016
Application:	ICC
Species:	Mouse

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Bioinformatics

Gene Symbol	OTX2
Uniprot	P32243()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

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Publications for Otx2 Antibody (AF1979)(163)

Reviews for Otx2 Antibody (AF1979) (2) 4.52

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