Nanog Antibody

Nanog is a newly identified homeodomain-bearing transcriptional factor. Nanog expression is specific to early embryos and pluripotential stem cells including mouse and human embryonic stem (ES) and embryonic germ (EG) cells. It is a key molecule involved in the signaling pathway for maintaining the capacity for self-renewal and pluripotency, bypassing regulation by the STAT3 pathway. Nanog mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Nanog-deficient ES cells lose pluripotency and differentiate into extraembryonic endoderm lineage. Thus it is one of the molecular markers suitable for recognizing the undifferentiated state of stem cells in the mouse and human. NANOG is a new marker for testicular carcinoma in situ and germ cell tumors. Nanog is a 304 amino acid polypeptide which lacks a signal sequence for secretion.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-59737	Applications	Species
Yasuda SY, Tsuneyoshi N, Sumi T et al. NANOG maintains self-renewal of primate ES cells in the absence of a feeder layer. Genes Cells 2006-09-01 [PMID: 16923129]

Array NB100-59737

• Nanog Antibodies
• Nanog Lysate
• Nanog Proteins