Musashi-1 Antibody

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Recently, expression of Musashi1 has been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in oncogenic development. Results suggest that Musashi1 expression may be an important factor in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection. (1). Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi1 controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signaling by repressing translation of the Notch inhibitor m-Numb (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publication 1 - 1 of 1.

Publication using NBP1-32812	Applications	Species
Lin, JC;Tsai, JT;Chao, TY;Ma, HI;Liu, WH; Musashi-1 Enhances Glioblastoma Migration by Promoting ICAM1 Translation Neoplasia 2019-04-05 [PMID: 30959276] (WB, IF/IHC, Human)	WB, IF/IHC	Human

Array NBP1-32812

• Musashi-1 Antibodies
• Musashi-1 Lysate
• Musashi-1 Proteins